上游充通大 SHANGHAI JIAO TONG UNIVERSITY polymyxins 国 detergents,selectively toxic for Gram- bacteria due to their specificity for the lipopolysaccharide(脂多糖)molecule strong nephrotoxic renewed interest duo to antimicrobial resistance
polymyxins detergents, selectively toxic for Gram- bacteria due to their specificity for the lipopolysaccharide（脂多糖） molecule strong nephrotoxic renewed interest duo to antimicrobial resistance
上游充通大 SHANGHAI JIAO TONG UNIVERSITY Macrolides（大环内酯类)
Macrolides（大环内酯类）
上游充通大 Macrolides(大环内酯类) SHANGHAI JIAO TONG UNIVERSITY 1949,Abelardo Aguilar H3C. CH3 soil samples to Eli Lilly HO. OH 、CH3 H3C H3C HO Erythromycin from H5C2 CH3 Streptomyces erythreus OCH3 (红色链霉菌) CH3 CH3 OH 1952,clinical uses CH3 1970's,clarithromycin (克拉霉素)，acid Erythromycin instability overcome 红霉素 azithromycin,…
Macrolides（大环内酯类） Erythromycin 红霉素 1949, Abelardo Aguilar soil samples to Eli Lilly Erythromycin from Streptomyces erythreus （红色链霉菌） 1952, clinical uses 1970’s, clarithromycin （克拉霉素），acid instability overcome azithromycin, …
OH OH N 罗红霉素Roxithromycin 0^0 Beckmann Rearraangement OH Erythromycin Oxime OH Dirithromycin HN OH 还原 甲基化， OH OH 阿齐霉素Azithromycin
阿齐霉素 Azithromycin Dirithromycin Erythromycin Oxime 罗红霉素 Roxithromycin 还原 甲基化 Beckmann Rearraangement O N OH O O OH O O OH O HO O N O O O O OH O O OH O O OH OHO O N OH N O OH O O OH O O OH OHO O N OH HN O OH O O OH O O OH OHO O N OH HN O O N OH O O OH O O OH O HO O N OH O O O O O OH O O OH O O OH O HO O N OH O N OH O O OH O O OH O HO O N OH OH