抗心律失常药 Anti-Arrhythmic Drug
抗心律失常药 Anti-Arrhythmic Drug
Content o Physiology of normal cardiac rhythm o Definition and mechanisms of arrhythmias o Classification of drugs to treat arrhythmias o Important anti-arrhythmic drugs (mechanism and pharmacological characteristics) o Arrhythmias in clinical practice
Content Physiology of normal cardiac rhythm Definition and mechanisms of arrhythmias Classification of drugs to treat arrhythmias Important anti-arrhythmic drugs (mechanism and pharmacological characteristics) Arrhythmias in clinical practice
Cardiac electrical activity and ECG Lead ll Sinus Node Atrium Left Bundle Branch AV Node Bundle of HIS Ventricles Right Bundle Branch
Cardiac electrical activity and ECG
Ion channels and AP Ica.L INa-ca 0A 0 3 INa 4
Ion channels and AP 0 1 2 3 4 INa ICa.L IKr IKs IK1 IK1 ITo1 INa-Ca
2 inward outward 3 Phase 4 Na+current Ca2+ L-type current T-type transient ITot (4-AP-sensitive) outward current ITo2 (Ca2+-activated) delayed rectifiers e (Ik) la or Ikp inward rectifier,Ik1 pacemaker current,(,see above) Na+-Ca2+exchange Nat,K+-ATPase