Agents used in blood 20 Department of Pharmacology
Agents used in blood Department of Pharmacology
Classification of drugs ●Anticoagulants ----Heparin,low molecular weight heparin ----Warfarin O Fibrinolytics Antipletelet drugs ● Treatment of bleeding ----Vitamin K ●Treatment of anemia ----Iron ----Cyanocobalamin (B12) ----Folic acid
●Anticoagulants ----Heparin, low molecular weight heparin ----Warfarin ● Fibrinolytics ● Antipletelet drugs ● Treatment of bleeding ----Vitamin K ● Treatment of anemia ----Iron ----Cyanocobalamin (B12) ----Folic acid Classification of drugs
Physiological hemostasis Damaged vessel Damaged endothelium Activated clotting vasospasm Platelet factors aggregation Platelet plug solid fibrin clot formed Arrest bleeding
Physiological hemostasis Damaged vessel vasospasm Activated clotting factors solid fibrin clot formed Platelet plug Arrest bleeding Platelet aggregation Damaged endothelium - -
Blood Clotting Factor Factor Name Plasma Synthesizing Half life Chromsome Concentration site site Fibrinogen 3000 Liver 4~5d 4 Il Prothrombin 100 Liver (with Vit K) 3d 11 Ill Tissue factor Endothelial cell IV Ca2+ 100 V Proaccelerin 10 Endothelial cell,platelet 12~15 h 1 VII Proconvertin 0.5 Liver (with Vit K) 4~7h 13 VII Antihemophilic factor,AHF 0.1 Liver 8~10h X IX Plasma thromboplastic 5 Liver (with Vit K) 24h X component,PTC(Christmas factor) X Stuart-Prower Factor 10 Liver(with Vit K) 2d 13 XI Plasma thromoboplastin 5 Liver 2~3d antecedent,PTA XII Contact factor or Hageman factor 40 Liver 24h 5 XIlI Fibrin-stabilizing factor 10 Liver,platelet 8d 6,1 High-molecular weight 80 Liver 3 kininogen,HMW-K Prekallikrein,Pre-K or Fletcher factor 35 Liver 、 4
I Fibrinogen 3000 Liver 4~5 d 4 II Prothrombin 100 Liver (with Vit K) 3 d 11 III Tissue factor - Endothelial cell - - IV Ca2+ 100 - - - V Proaccelerin 10 Endothelial cell, platelet 12~15 h 1 Ⅶ Proconvertin 0.5 Liver (with Vit K) 4~7 h 13 Ⅷ Antihemophilic factor,AHF 0.1 Liver 8~10 h Ⅹ Ⅸ Plasma thromboplastic 5 Liver (with Vit K) 24 h Ⅹ component,PTC(Christmas factor) Ⅹ Stuart-Prower Factor 10 Liver (with Vit K) 2 d 13 Ⅺ Plasma thromoboplastin 5 Liver 2~3 d 4 antecedent,PTA Ⅻ Contact factor or Hageman factor 40 Liver 24 h 5 XIII Fibrin-stabilizing factor 10 Liver, platelet 8 d 6,1 - High-molecular weight 80 Liver - 3 kininogen,HMW-K - Prekallikrein,Pre-K or Fletcher factor 35 Liver - 4 Factor Name Plasma Synthesizing Half life Chromsome Concentration site site Blood Clotting Factor Blood Clotting Factor
Mechanism of Blood Coagulation Intrinsic pathway Extrinsic pathway Collagen or other Damage exposes activators tissue factor(Ill) Active XII Tissue factor Ca2+ (Ill)and XI Active active Vll XI positive feedback Ca2+ Active X VIn Ca2+,PL X Active X Common pathway Ca2+,V,PL ---------positive feedback------------ Thrombin Prothrombin PL=phospholipids Fibrinogen Fibrin XI Active XIll Cross-linked fibrin
Mechanism of Blood Coagulation Mechanism of Blood Coagulation