上泽充通大学 Shanghai Jiao Tong Univer.. Immunopharmacology 免疫药理学 2010.12
Immunopharmacology 免疫药理学 2010.12
h 上游充通大￥ 后 Shanghai Jiao Tong University Types of Drugs Immunosuppressants (important!) Immunostimulants Immunomodulators e Induction of tolerance(tolerogens) Cytokines Hematopoetic growth factors Antibodies targeting key cell receptors/ligands
Shanghai Jiao Tong University Types of Drugs Immunosuppressants (important!) Immunostimulants Immunomodulators • Induction of tolerance (tolerogens) • Cytokines • Hematopoetic growth factors • Antibodies targeting key cell receptors/ligands
上游充通大 Simplified schematic of an immune response Shanghai Jiao Tong University proliferation differentiation CD8+T cells -CD8+cytolytic T cells Class I IFNy,IL-2 proliferation APC Class Il CD4+T cells differentiation CD4+immune cells Cytokines (delayed hypersensitivity Costim.Mol. L-4,-5,-6 Protein antigens B cells Plasma cells proliferation ↓ MHC class Il/peptides differentiation antibody APCs production
Shanghai Jiao Tong University Simplified schematic of an immune response Class I MHC class II/peptides APCs Protein antigens CD8+ T cells CD4+ T cells B cells Plasma cells CD8+ cytolytic T cells CD4+ immune cells (delayed hypersensitivity) antibody production proliferation & differentiation IFNg, IL-2 Cytokines Costim. Mol. IL-4,-5,-6 proliferation & differentiation APC Class II proliferation & differentiation
上商充通大 Major steps in immune responses 后 Shanghai Jiao Tong University Antigen CD8 T cell IL-2 ◆cytotoxic 4 T cells primed CD4 L-1 IL-2 T helper antigen CD4 cell presenting T helper plasma cell cell 4 cells (macrophage, IL-2 dendritic cell) B cell
Shanghai Jiao Tong University Antigen antigen presenting cell (macrophage, dendritic cell) CD4 T helper cell primed CD4 T helper cell CD8 T cell cytotoxic T cells plasma cells 1 2 3 4 4 IL-1 IL-2 IL-2 IL-2 Major steps in immune responses B cell
上游充通大￥ Sites of action of 后 Shanghai Jiao Tong University immunosuppressive drugs Antigen CD8Tce生 IL-2 cytotoxic E T cells 3 X primed D CD4 BIL-1 IL-2 T helper antigen CD4 cell presenting T helper 4 plasma cell cell X→ cells cytokines
Shanghai Jiao Tong University Antigen antigen presenting cell CD4 T helper cell primed CD4 T helper cell CD8 T cell cytotoxic T cells plasma cells 1 2 3 4 4 IL-1 IL-2 IL-2 cytokines Sites of action of immunosuppressive drugs X X X X X A B D D E C X