Drugs for Congestive Heart Failure
Drugs for Congestive Drugs for Congestive Heart Failure Heart Failure
What Are The Symptoms of Heart Failure? Think FACES ... -Fatigue -Activities limited Chest congestion -Edema or ankle swelling -Shortness of breath
Think FACES... •Fatigue •Activities limited •Chest congestion •Edema or ankle swelling •Shortness of breath What Are The Symptoms What Are The Symptoms of Heart Failure? of Heart Failure?
New York Heart Association NYHA NYHA I级：日常活动不出现心力衰竭症状 NYHAⅡ级：日常话动即诱发症状 NYHAⅢ级：轻度运动即诱发症状 NYHA IV级：休息状态即出现症状
New York Heart Association (NYHA) New York Heart Association (NYHA) NYHA Ⅰ级：日常活动不出现心力衰竭症状 NYHA Ⅱ级：日常活动即诱发症状 NYHA Ⅲ级：轻度运动即诱发症状 NYHA Ⅳ级：休息状态即出现症状
Cardiac dysfunction Contractility↓，Relaxation) Cardiac output↓ Cardiac Vessel B1-R↓ Constriction 米RAAtCA ↓ Contractility Sodium and water Compliance↓ *Preloadt Resistance Compliance↓ retention Afterload Blood ardiac hypertrophy and volume reconstruction Vessel hypertrophy and reconstruction ↓ Returning blood Edema volume↑ Phathophysiology of Heart Failure
Cardiac dysfunction (Contractility↓，Relaxation↓) Cardiac output ↓ Sodium and water retention Blood volume↑ Edema Vessel Constriction Resistance↑ Compliance↓ Afterload↑ Vessel hypertrophy and reconstruction Cardiac β1-R↓ Contractility Compliance↓ Cardiac hypertrophy and reconstruction Returning blood volume↑ Preload↑ RAA↑CA↑ Phathophysiology of Heart Failure
Drugs used in CHF Cardiac glycosides:digoxin,cedilanide RAS inhibitors: DiuretiCS:hydrochlorothiazide,furosemide Beta-blockers Vasodilators Others
Drugs used in CHF Drugs used in CHF Cardiac glycosides: digoxin, cedilanide RAS inhibitors: Diuretics: hydrochlorothiazide, furosemide Beta-blockers Vasodilators Others