Primarypulmonarytuberculosis
Primary pulmonary tuberculosis
Primary pulmonary TB is atuberculosisthat is caused by primary pulmonaryinfection of M.tuberculosis. Primary pulmonary TBincludesPrimary complexTuberculosis of trachebronchial lymphnodes
□ Primary pulmonary TB is a tuberculosis that is c a u se d by primary pulmonary infection of M. tuberculosis. □ Primary pulmonary TBincludes P r imar y complex Tuberculosis of trachebronchial lymphnodes
PathogenesisDroplet nucleialveoliIngestion byPAM'SinhalationIntracellularreplicationof bacilliDestruction ofbacillidestructionof PAM'STubercleformationLymphogenicspreadHilar lymph nodesPrimary focuslymphangitislym phadenitisPathogenesischdPrimary complexprimarytousPAM: pulmonary alveolarmacrophagesrimarycomple
Droplet nuclei inhalation alveoli Ingestion byPAM’S Intracellular replication of bacilli Destruction ofbacilli destructionof PAM’S Tubercle formation Lymphogenic spread Hilar lymph nodes Primary focus lymphangitis lym phadenitis Pathogenesis Primary complex PAM: pulmonary alveolarmacrophages
Primary focusLymphangitisLymphadenitis700typicalatypicalTuberculosis oftrachebronchial lymphnodesprimary complexPrimary palmonary tuberculosis
－ Tuberculosis of trachebronchial lymphnod es Primary palmonary tuberculosis typical atypical primary complex Lymphadenitis Primary focus Lymphangitis
PathologyLocation of primary focus : lowzones oflobus superior pulmonis or upperzone of lobus inferiorpulmonis subpleural right lung mostlyBasic lesions : exudative lesions:epithelioid cells,lymphocytes,andfibroblasts proliferative lesions: tubercle, tuberculous granuloma caseous necrosis
Pathology Location of primary focus : □ low zon es of lobus superior pulmonis or u p p er zone of lobus inferior pulmonis □ subpleural □ right lung mostly B a s i c lesions ： □ exudative lesions: □ epithelioid cells, lymphocytes, a n d fibroblasts □ proliferative lesions: □ tubercle, tuberculous granuloma □ ca seou s n ecrosis