INFANTILEDIARRHEA
1 INFANTILE DIARRHEA
Infantile diarrheaWhat is the diarrhea?Why diarrhea is highly susceptible tochildren?Why diarrhea is more dangerous for children?百 What isthe causes ofdiarrhea?What is the diarrhea manifestation? How to diagnose diarrhea?What is the most important points in treatment ofTdiarrhea?What should we pay more attentionto, when fluidtherapy is erfomed a data taueChildren's Hospital
Infantile diarrhea Children's Hospital 2 □ What is the diarrhea? □ Why diarrhea is highly susceptible tochildren? □ Why diarrhea is more dangerous for children ? □ What is the causes of diarrhea? □ What is the diarrhea manifestation? □ How to diagnose diarrhea? □ What is the most important points in treatment of diarrhea? □ What should we pay more attention to, when fluid therapy is performi enfd an ?tile diarrhea Dr.zhanxue
InfantileDiarrheaBackground口Disease burdenDefinitionEtiology ofdiarrhea-Infectivefactors-Non-infective factorsPathogenesis ofviral,Enterotoxigenic,enteroinvasivediarrheaClinical manifestations-dehydration, metabolic acidosis..Clews of diagnosis fordiarrheaTreatment of diarrheaFluidtherapyAssessment of dehydration..infantile diarrhea Dr.zhanxueChildren's Hospital
□ Background □ Disease burden □ Definition □ Etiology of diarrhea - Infective factors - Non-infective factors □ Pathogenesis of viral, Enterotoxigenic, enteroinvasive diarrhea □ Clinical manifestations -dehydration, metabolic acidosis. □ Clews of diagnosis for diarrhea □ Treatment of diarrhea □ Fluid therapy □ Assessment of dehydration. infantile diarrhea Dr.zhanxue Children's Hospital 3 Infantile Diarrhea
BackgroundDiarrhea is a clinical syndrome caused by diverseetiology.It is the second most frequent childhood disease justnexttotherespiratoryinfectionIt is the major cause of death among world's childrenespecially in children under five years old in manydeveloping countries.infantile diarrhea Dr.zhanxueChildren's Hospital4
Background □Diarrhea is a clinical syndrome caused by diverse etiology. □It is the second most frequent childhood disease just next to the respiratory infection. □It is the major cause of death among world’s children especially in children under five years old in many developing countries. infantile diarrhea Dr.zhanxue Children's Hospital 4
BackgroundDisease burdenDefinitionEtiology ofdiarrheaInfective factors-Non-infective factorsPathogenesis of viral diarrheaDiseaseBurdenPathogenesis ofentrotoxinicdiarrheaPathogenesis of entroinvasivedarrheaClinical manifestationsWorldwide-dehydration,metabolicacidosisClews ofdiagnosis fordiarrhea 3-5billion episodes ofdiarrhea/yearTreatment ofdiarrheaFluid therapy 4-5 million deaths/year (serious diarrhea/dehydration)Assessment of dehydrationChildren are the predominant populationsReplacement of fluid3.2billion episodes1.3milliondeaths/year(<5yearsold)口In China836million episodesinpediatrics,1/4-1/3ofalloutpatientsMortality ofdiarrhea 51/10000During 1993~2006, ChildrensHospital,C QM U1/3of clinicvisitpatients口22910 inpatients with diarrhea?(among ofall hospitalizations,8.86%inpatients due to diarrhea)5
5 Disease Burden Worldwide □ 3-5 billion episodes of diarrhea/year, Childrenarethepredominant populations □ 3.2 billion episodes □ 1.3 million deaths/ year (< 5years old) In China 836 million episodes in pediatrics, 1/4~1/3 of all outpatients Mortality of diarrhea 51/10 000. During 1993~2006, Children’sHospital, CQMU □ 1/3 of clinic visit patients □ 22 910 inpatients with diarrhea (among of all hospitalizations, 8.86% inpatients due to diarrhea). □ 4-5 million deaths/year (serious diarrhea/dehydr ation) □ Background □ Disease burden □ Definition □ Etiology of diarrhea - Infective factors - Non-infective factors □ Pathogenesis of viral diarrhea □ Pathogenesis of entrotoxinic diarrhea Pathogenesis of entroinvasive diarrhea □ Clinical manifestations -dehydration, metabolic acidosis. □ Clews of diagnosis for diarrhea □ Treatment of diarrhea Fluid therapy □ Assessment of dehydration □ Replacement of fluid