Growth hormone deficiency(pituitary dwarfism)
Growth hormone deficiency (pituitary dwarfism)
O utlin eGHD occurs when anterior pituitary synthetize andsecrete growth hormone insufficient partly orcompletely, lead to the disorders of growth anddevelopment , the length / heights are less than 3rdpercentile or 2SD below the mean normalrange.Disease incidence:2/10000~2.5/10000
GHD occurs when anterior pituitary synthetize and secrete growth hormone insufficient partly or completely, lead to the disorders of growth and development，the length /heights are less than 3rd percentile or 2SDbelow the mean normalrange. Disease incidence: 2/10000~2.5/10000 O u tline
Y00000XDBooooooohuman GH isa protein with 19l amino acides,single chain, molecular wieght: 22KD
h u m a n G H is a protein with 191 amino acides, single chain, molecular wieght: 22KD
Physiologic functionBasic function:GHpromotes anabolic metabolism:Promoting protein synthesis, stimulating hepaticglycogen decompose and lipoclasis-muscles, tissue, organ cells proliferation1childen growth and development
Basic function: GH promotes anabolicmetabolism: Promoting protein synthesis, stimulating hepatic glycogen decompose and lipoclasis ↓ muscles, tissue, organ cells proliferation ↓ childen growth and development Physiologic function
Physiologic function: Specialfunction :GH promotes skeleton growing:Promote epiphyseal cartilage cellsproliferating, and bony matrix deposition1epiphysealplate thickening1bone longitudinalgrowing, height increasing
Physiologic function • Special function： G H promotes skeleton growing: Pr o mote epiphyseal cartilage cells proliferating, and bony matrix deposition ↓ epiphysealplate thickening ↓ bone longitudinal growing, height increasing