Hypoxic-ischemic(HIE)encephalopathy新生儿缺氧缺血性脑病
Hypoxic-ischemic encephalopat hy (HI E) 新生儿缺氧缺血性脑病
OutlineNeonatal asphyxia-→oxygen-poor→ischemia→brain injured in perinatalperiodCurrent ly birth trauma , O2 deficiency&asphyxia ↑Severe consequence :neonatal death orchildren disablement, one of reason ofcerebral palsy in childrenhood. Commonin full term bb, also in premature
• Neonatal asphyxia→oxygen-poor →ischemia→brain injured in perinatal period • Cur r ent ly birt h t r auma↓，O2 deficiency &asphyxia↑ • Severe consequence ：neonatal death or children disablement, one of reason of cerebral palsy in childrenhood. • Common in full term bb, also in premature
causesPlacenta&umbilicafecotud smothershypoxiaAnte-&intr apart umantepartumintrapaPrOtSutmpartum20%35%35%10%
causes mot hers antepartum 20％ int r apart um 35％ 35％ 10％ hypoxia Placenta & umbilicaf le cot ru d s Ante- & intrapaprot su tmpartum
CausesofHIEalso causes of asphyxia:Maternal factors:illnesses,obstetricdeseases,smokingordrugaddictionpregnancies,olderthan35yearsteenageIntrapartum factors: umbilicalcore, malpositionplacental insufficiency,placental abruption· Fetal factors: congenital anomalies, IUGRhydrops fetalisapnea, HMD, MAS, PPHN, shock.Infant factors:
Causes of HIE also causes of asphyxia: • Maternal factors： illnesses， obstetric deseases，smoking or drug addiction, teenage pregnancies, older than 3 5 years • Intrapartum factors：umbilical core，malposition, placental insufficiency, placental abruption • Fetal factors：congenital anomalies, IUGR， hydrops fetalis • Infant factors： apnea, HMD, MAS, PPHN, shock
Etiopathogenesis of HIECerebral blood flow (CBF)I. fail incompensation:2 steps of redistribution
Etiopathogenesis of HIE Cerebral blood flow (CBF)： 1. fail in compensation： 2 steps of redistribution