Further classification of?Group AB-HemolyticStreptococcipecificcapsule Type通MGAS can beprotein antigenssubdivided intocarbohydratesmore than 80peptidoglycancell coattypies ofcytoplasmstreptococcibased on thecell wallantigenicaldifference ofSketch Map of StructureMproteinofStreptococciDIVISION OFINFECTIOUS DISEASE ANDGASTROENTEROLOGY
GAS can be subdivided into more than 80 typies of streptococci based on the antigenical difference of M p r o t e i n Further classification of Group Aβ- Hemolytic Streptococci DIVISION O F INFECTIO US DISEAS E AND GASTRO ENT E RO LO GY Type -s pe c ific M protein
ClassificationofStreptococci?StreptococciHemolytic patternComplete Hemolysis:B-hemolyticstreptococciComplete Hemolysis:Partially Hemolysis:β-hemolytic streptococcihemolyticstreptococciNo hemolysis:Group-specific carbohydratey-hemolyticstrentocoeo20groups AtoH K tovGroup Aβ-hemolyticstreptococciType-specific MproteinMore than 8oserotypesDIVISION OFINFECTIOUS DISEASE ANDGASTROENTEROLOGY
Classification of Streptococci G r o u p A β - h e m o l y t i c s t r e p t o c o c c i M o r e t h a n 8 0 s e r o t y p e s C o m p l e t e H e mo l ysi s: β- hemolytic streptococci □ C o m p l e t e He mol ys i s : β- hemolytic str e ptococci □ P art i al l y He mol ys i s : α- hemolytic str e ptococci □ N o he mol ys i s : γ- hemolytic str e ptococci Group-specific carbohydrate Type-specific M protein Streptococci Hemolytic pattern 20 gr oup s A to H K to V DIVISION O F INFECTIO US DISEAS E AND GASTRO ENT E RO LO GY
?ClassificationofStreptococciGroup A β- hemolytic streptococci is the mostimportant pathogenicstreptococci.More than 95%streptococcidiseaseis leadedbyGAsDIVISION OFINFECTIOUS DISEASE AND GASTROENTEROLOGY
Classification of Streptococci □ Gr oup A β- hemolytic streptococ c i is the most impor tant pa thoge nic streptoc occ i. More than 95% str e ptococci dise a se is le a de d by GAS. DIVISION O F INFECTIO US DISEAS E AND GASTRO ENT E RO LO GY
Scarlet Fever?ClassificationofStreptococciVirulence ofGroupAβ-hemolytic streptococciEpidemiologyPathophysiology Clinical Manifestations Complications Lab studiesDiagnosis &DifferentialDiagnosis TreatmentPrognosisDIVISION OFINFECTIOUS DISEASE ANDGASTROENTEROLOGY
Scarlet Fever DIVISION O F INFECTIO US DISEAS E AND GASTRO ENT E RO LO GY □ Classification of Streptococci □ Virulence of Group A β - hemolytic streptococci □ Epidemiology □ Pathophysiology □ Clinical Manifestations □ Complications □ Lab studies □ Diagnosis & Differential Diagnosis □ Treatment □ Prognosis
Virulenceof GroupAβ-hemolytic streptococci(S. Pyogenes)Structuralcompositions ofGAs Hyaluronic Acid CapsuleMprotein口 Lipoteichoic acid (LTA) Fibronectin-binding protein (F protein) Secretion products of GAs Erythrogenic toxins (Pyogenic exotoxins)Hemolysin O, Hemolysin S (SLO & SLS)HyaluronidaseStreptokinase (SK)口Streptodornase (SD)口DIVISION OFINFECTIOUS DISEASE ANDGASTROENTEROLOGY
Virulence of Group A β – hemolytic streptococci (S. Pyogenes) □ S t r u c t u r a l c o m p o s i t i o n s of GAS □ Hyaluronic Acid Capsule □ M protein □ Lipoteichoic acid (LTA) □ Fibronectin-binding protein (F protein) □ S e c r e t i o n p r o d u c t s of GAS □ Erythrogenic toxins (Pyogenic exotoxins) □ Hemolysin O, Hemolysin S (SLO & SLS) □ Hyaluronidase □ Streptokinase (SK) □ Streptodornase (SD) DIVISION O F INFECTIO US DISEAS E AND GASTRO ENT E RO LO GY