BIOMATERIALS-TISSUE INTERACTIONS Effects of biomaterials on Tissue In bulk form Tissue formation Attachment Remodeling In Particle Molecular) Form Tissue degradation
BIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS INTERACTIONS Effects of Biomaterials on Effects of Biomaterials on Tissue • In Bulk Form In Bulk Form –Tissue formation Tissue formation –Attachment Attachment –Remodeling Remodeling • In Particle (Molecular) Form In Particle (Molecular) Form –Tissue degradation Tissue degradation
BIOMATERIALS-TISSUE INTERACTIONS Effects of Biomaterials on cells In bulk form Cell attachment Cell proliferation(mitosis) Production of matrix molecules and enzymes(synthesis) Migration Contraction Release of pre-packaged reactive molecules(exocytosis In Particle(Molecular) Form Ingestion of particles(endocytosis)
BIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS INTERACTIONS Effects of Biomaterials on Effects of Biomaterials on Cells • In Bulk Form In Bulk Form – Cell attachment Cell attachment – Cell proliferation ( Cell proliferation (mitosis mitosis ) – Production of matrix molecules and Production of matrix molecules and enzymes ( enzymes (synthesis synthesis ) – Migration Migration – Contraction Contraction – Release of pre Release of pre -packaged reactive packaged reactive molecules ( molecules (exocytosis exocytosis ) • In Particle (Molecular) Form In Particle (Molecular) Form – Ingestion of particles ( Ingestion of particles (endocytosis endocytosis )
BIOMATERIALS-TISSUE INTERACTIONS Permanent biomaterials ° Positive response Tissue attachment ° Adverse responses Contraction Reaction to particles; tissue destruction ° Passive response
BIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS INTERACTIONS Permanent Biomaterials Permanent Biomaterials • Positive Response Positive Response –Tissue attachment Tissue attachment • Adverse Responses Adverse Responses –Contraction Contraction –Reaction to particles; Reaction to particles; tissue destruction tissue destruction • Passive Response Passive Response
Total Hip and Knee replacement Prostheses Images removed due to copyright considerations
Total Hip and Knee Replacement Prostheses Images removed d u e to co p yri g ht consi derations
BIOMATERIALS-TISSUE INTERACTIONS Permanent biomaterials ° Positive response Tissue attachment ° Adverse responses Contraction Reaction to particles; tissue destruction ° Passive response
BIOMATERIALS BIOMATERIALS -TISSUE INTERACTIONS INTERACTIONS Permanent Biomaterials Permanent Biomaterials • Positive Response Positive Response –Tissue attachment Tissue attachment • Adverse Responses Adverse Responses –Contraction Contraction –Reaction to particles; Reaction to particles; tissue destruction tissue destruction • Passive Response Passive Response