2. Capacitance Venules 3. Pump output Heart CNS- Sympathetic nerves 4. Volume 1. Resistance Kidneys Arterioles Renin Aldosterone Angiotensin Regulation of blood pressure (neural endocrine pathways)
Vasomotor center Methyldopa Guanabenz Sympathetic nerve terminals Guanethidine guanadrel Sympathetic Regulation of blood pressure: Sympathetic ganglia B-Receptors of heart Trimethaphan Propranolol and other B-blocke Targets of antihypertensive Angiotensin a-Receptors of vessels Vascular smooth muscle receptors of vessels Prazosin and Hydralazine Verapamil and other Losartan and other a, blockers calcium channel rugs other angiotensin Nitroprusside blockers receptor blockers B-Receptors of juxtaglomerular cells that release renin Thiazides, etc Propranolol and Endocrine/body fluid converting enzyme Angiotensin‖l Renin sInogen Captopril and other ACE inhibitors
Arenas Arterioles From ve c Vasoconstriction o arteriole (increased cont acton of eircular smooth muscle in the artena Heart contracting and emptying wall, whch leads to aused by: increased resistance I Myogenic actvily Oxygen (o) Carbon doxide(CoJ and other metabolite I Sympathetic ssmutason Vasopresin, a^ lotensin目 Arteries Vasodilation T下FFF Arenales of cicuta smooth musee in te arter oar wa, which leads to Caused by: tt_t decreased resistance and ncreased now I cO, and other medabots 4 Sympathetic stimulation Heart relaxing and filling Peripheral resistance and vascular tone and elasticity
Collagenic smoot msoe Normal blood cap of plaque Lpd.ch core Endowel Arterial wall hypertrophy and sclerosis
B Classification of Antihypertensive Drugs Diuretics Sympathetic nervous system inhibitors mainly, adrenoceptor antagonists Calcium channel blockers Regin-angiotensin system inhibitors Others Central antihypertensive drugs Vasodilators