Chlorpromazine (2) Effects on autonomic nervous system a)Hypotensive effects a receptor blockade, postural hypotension b)Anticholinergic effects dry mouth, constipation, blurred vision, urinary retention, increased intraocular pressure, etc 16
(2) Effects on autonomic nervous system a) Hypotensive effects receptor blockade, postural hypotension b) Anticholinergic effects dry mouth, constipation, blurred vision, urinary retention, increased intraocular pressure, etc. Chlorpromazine 16
Chlorpromazine (3)Endocrine effects (Tuberohypophyseal pathway blockade Prolactin T(breast swelling pain and lactation) Estrogen, progestin, ACTH, growth hormone V 17
(3) Endocrine effects (Tuberohypophyseal pathway blockade) Prolactin (breast swelling, pain and lactation) Estrogen, progestin, ACTH, growth hormone Chlorpromazine 17
Chlorpromazine 2. Clinical uses (1)Treatment and prevention of acute schizophrenia and mania (2) Treatment of emesis and hiccough but ineffective on motion sickness (3 Hypothermic anesthesia and artificial hibernation combined with lowering room temperature 18
2. Clinical uses (1) Treatment and prevention of acute schizophrenia and mania (2) Treatment of emesis and hiccough but ineffective on motion sickness (3) Hypothermic anesthesia and artificial hibernation combined with lowering room temperature Chlorpromazine 18
Chlorpromazine 3. Side effects Motor disturbance(extrapyramidal syndrome,EPS proportional to D2 blockade of nigrostriatal pathway Acute: dystonia(twisting and repetitive movements or abnormal postures), akathisia(inability to sit stil misnomer, stiffness, tremor(parkinsonism),occur commonly in the first few weeks, often declining with time, and are reversible 19
3. Side effects • Motor disturbance (extrapyramidal syndrome, EPS ) - proportional to D2 blockade of nigrostriatal pathway - Acute: dystonia (twisting and repetitive movements or abnormal postures), akathisia (inability to sit still), misnomer, stiffness, tremor (parkinsonism), occur commonly in the first few weeks, often declining with time, and are reversible. Chlorpromazine 19
Chlorpromazine 3. Side effects Motor disturbance(extrapyramidal syndrome,EPS) Acute dystonia mAChR antagonists may counteract acute dystonia
3. Side effects • Motor disturbance (extrapyramidal syndrome, EPS ) - Acute dystonia Chlorpromazine mAChR antagonists may counteract acute dystonia 20