动物脂肪酸合酶 COoH H2 ACP 一·tm x ;o-P-OASH 6 HSMO-P-O AC 3
动物脂肪酸合酶
Substrate entry Acetyl-CoA Malonyl-CoA TEase Domain 1: Acyl and malonyl binding and condensation C ACP KRL DH 阝 Ketoacyl synthase KSase HS ER cetyl transferase ATase Chain elongation MTase Malonyl transferase MTase 动物脂肪酸合 Chain Domain 2: Reduction of elongation Ist domain I intermediate KSase LER Enoyl-ACP reductase 阝 Ketoacyl reductase HS. DH ACP Dehydratase AcetyI-COA TEase Malonyl-CoA Thioesterase Substrate entry Domain 3: Liberation of palmitate product
动物脂肪酸合酶
脂肪酸合成工 OOC O CH3-C-S一COA CHo-C-S-CoA Acetyl-COA Malonyl-CoA Acetyl ACP-SH ACP-SH Malonyl transferase transferase COASH S COASH CH9-C-S- ACP OOC- CH, -- ACP KSase KSase: Malonyl-ACP B-酮酰ACP合酶N ACP-SH CHs-C-S-KSase CHs-C-CHa-C--S- ACP AcetoacetyI-ACP
脂肪酸合成Ⅰ KSase: β-酮酰ACP合酶
CH3-C-CH2-C-$- ACP Acetoacetyl-ACP NadPh B-KetoacyI-ACP reductase S> NADP+ OH CHs-C-CH-C--S-ACP H D-p-Hydroxybutyryl-ACP 脂肪酸合成 Note that these three steps are the B-Hydroxyacyl- reverse of those in ACP dehydratase B。 oxidation (see Chapter 24) CH3-C=C-C-S- ACP H Crotonyl-ACP
脂肪酸合成Ⅱ
H CH3--C=C-C-$- ACP 在动物中,脂 H 肪酸的合成到 Crotonyl-ACP 16碳脂肪酸即脂 NADPH +H 软脂酸为止。 2.3-Arans-Enovl ACP reductase 肪 NADP+ 酸 CHs- CHy- CH,$- ACP Butyryk-ACP 成 6 cycles加上新的丙二酰ACP,链向羧基端延伸 CH3-(CH,)1-C-$- ACP Animal cells 2 CH9(CH )14-COO Palmitoyl-ACP Palmitate H20 ACP-SH
脂 肪 酸 合 成 Ⅲ 在动物中，脂 肪酸的合成到 16碳脂肪酸即 软脂酸为止。 加上新的丙二酰ACP，链向羧基端延伸