而液凝固过程为多种凝而因子参与的一系列蛋白质有限水解过程。已知的凝血因子有十二种，尚有前激肽释放酶、激肽释放酶、高分子激肽原和血小板磷脂。凝血过程分为三个阶段：·因子×的激活·凝血酶的形成·纤维蛋白的形成
血液凝固过程 为多种凝血因子参与的一系列蛋白质有限水 解过程。已知的凝血因子有十二种，尚有前 激肽释放酶、激肽释放酶、高分子激肽原和 血小板磷脂。凝血过程分为三个阶段： • 因子Ⅹ的激活 • 凝血酶的形成 • 纤维蛋白的形成
intrinsicpathwaydamagedtissuekininogenkallikreinXIDXIIextrinsicpathwaytraumaXIXIvIDIXIXVIIthrombintissue factorVILIVIIDXXX4thrombinVVprothrombinthrombin*fibrinogenfibrinllthrombinXIXIIIfibrin!@1999-2004NewSciencePress
内源性抗凝血药HMWK、KaXIXIa外源性HMWKTPLXIXIaVIa-VIIXIXa凝血过程Ca2+ PL TPLCa2+ PL VIIXXaCa2+ PL V1-HaIIaEXEa
凝 血 过 程 内源性 Ⅻ─→Ⅻa Ⅺ─→Ⅺa Ⅸ─→Ⅸa Ⅶa←─Ⅶ Ⅹ─→Ⅹa Ⅱ─→Ⅱa ⅩⅢ→ⅩⅢa HMWK、Ka HMWK Ⅰ─→Ⅰa 外源性 TPL 抗凝血药 Ca2+ PL Ⅷ Ca2+ PL Ⅴ Ca2+ PL TPL
intrinsicpathwayfactor XII>XIIaRemember that all these serineproteolysisproteases need calcium ions.This is why citrate and EDTAfactor XIXIawork as anti-coagulants forblood samples.proteolysisfactorIXIXaextrinsic pathwayfactor VIIaproteolysisfactorVII +tissuefactorphospholipidby"tenasefrom plateletscomplex"calciumionsfactor X>Xa<factorXproteolysisproteolysisIprothrombin>thrombinproteolysisproteolysis4fibrinogen>fibrin
Extrinsic pathwayIntrinsic pathwayHMw-karinogonFaxaFadloKallikroinHMw.kininogenFictorXFachocxoCalTissvefactorContactactivation patiwayFoctorViayFactoViCa2-EorFactortxCaztCal+PlatolotsVoCommon pathway+FactorXanFactorxFoctorXaCaPlatuletsWPeoenronbinIvomn(la)ProthrombinactvationFsccrtromotsFibrinogenFibrinFibrnopegtidesAandBWound healing