Chlorpromazine CH3 CH3
Chlorpromazine
Story of chlorpromazine discovery 1949.4,French navy surgeon Henri Laborit,studied anti-shock drug promethazine(异丙嗪)，partial success structure modification ↓ chlorpromazine 1950,given to the wounded soldiers:anti- shock;body temperature↓；quiet
1949.4，French navy surgeon Henri Laborit, studied anti-shock drug promethazine （异丙嗪）, partial success structure modification ↓ chlorpromazine 1950, given to the wounded soldiers: antishock; body temperature ↓; quiet Story of chlorpromazine discovery
Story of chlorpromazine discovery Associating with treatment of psychotic patients Psychiatrist Pierre Deniker tried and succeeded in those kinds of patients Smith Kline company revenues a lot Milestone of psychopharmacology
• Associating with treatment of psychotic patients • Psychiatrist Pierre Deniker tried and succeeded in those kinds of patients • Smith Kline company revenues a lot • Milestone of psychopharmacology Story of chlorpromazine discovery
Impact of antipsychotics.. 200 100 1900 1915 1930 1945 1960 1975 Fig.28.6 Patient population in public mental hospitals in the U.S.A.(From:Bassuk E L,Gerson S 1978 Scientific American 238:46)
Impact of antipsychotics
Mechanisms,actions and uses of Chlorpromazine Overall mechanism:blockade of DA,a, M,H1,5-HT receptors Actions and uses: 1,CNS (1)antipsychotic action Used mainly for schizophrenia
Mechanisms, actions and uses of Chlorpromazine Overall mechanism: blockade of DA, α, M, H1 , 5-HT receptors Actions and uses: 1, CNS （ 1 ）antipsychotic action Used mainly for schizophrenia