Aminoglycosides(氨基糖苷 类)and polymyxins多粘菌素) Macrolides（大环内酯类) and other antibiotics
Aminoglycosides（氨基糖苷 类）and polymyxins 多粘菌素） Macrolides（大环内酯类） and other antibiotics
Aminoglycosides(氨基糖苷 类) Tuberculosis,still severe infectious disease now 1882,Heinrich Hermann Robert Koch discovered M.tuberculosis(结核分枝杆菌) 1940's,Merck supported S.A.Waksman's lab, Rutgers university,NJ ·1940,actinomycin(放线菌素)，toxic ·1942,streptothricin(链丝菌素)，still toxic 1943,Albert Schatz,PhD student,entered lab
Aminoglycosides（氨基糖苷 类） • Tuberculosis, still severe infectious disease now • 1882, Heinrich Hermann Robert Koch discovered M. tuberculosis （结核分枝杆菌） • 1940’s, Merck supported S.A. Waksman’s lab, Rutgers university, NJ • 1940, actinomycin（放线菌素）, toxic • 1942, streptothricin （链丝菌素），still toxic • 1943, Albert Schatz, PhD student, entered lab
Aminoglycosides 1943.6 returned from army HO 0ct19,1943, OH streptomycin isolated HO… 一NH2 1944,Mayo clinic clinical trial HO HN-CH3 OH NH2 一NH2 1946,graduated and H2N patent left in Rutgers 1947,succeeded in Streptomycin(链霉素) TB treatment Law suit 1952,Nobel Prize to Waksman
Aminoglycosides 1943.6 returned from army Oct 19, 1943 ， streptomycin isolated 1944, Mayo clinic clinical trial 1946, graduated and patent left in Rutgers 1947, succeeded in TB treatment Law suit 1952, Nobel Prize to Waksman Streptomycin（链霉素）
30 人/10万 2的 结核 脑血管疾病 01 铂 癌 1QU 心血管疾病 50 10 191D 1920 1033 识HO 105A0 100 1970 1P80 年 本世纪三大流因及结核的死亡率变化
The Nobel Prize in Physiology or Medicine 1952 "for his discovery of streptomycin,the first antibiotic effective against tuberculosis" Selman Abraham Waksman