上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Drugs for Congestive Heart Failure ANMAN CHANCHAL HAO TONG UNIVEDSYNN
Drugs for Congestive Heart Failure Drugs for Congestive Heart Failure
上游充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 What Are The Symptoms of Heart Failure? Think FACES -Fatigue -Activities limited Chest congestion -Edema or ankle swelling -Shortness of breath
Think FACES... •Fatigue •Activities limited •Chest congestion •Edema or ankle swelling •Shortness of breath What Are The Symptoms What Are The Symptoms of Heart Failure? of Heart Failure?
上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Renal perfusion Activation of renin-angiotensin- adosterone system ↓Cardiac ↓Firing of arterial Activation of output baroreceptors Vasoconstriction sympathetic (Carotid sinus, Salt and water retention nervous system Aortic arch) Endothelial ↑Endothelin Short-term dysfunction ↓Nitric oxide Maintenance of bood pressure Longer-term Worsening of tissue perfusion Worsening of fluid retention Progressive cardiomyocyte death and fibrosis Death
上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Drugs used in CHF Cardiac glycosides:digoxin,cedilanide RAS inhibitors: Diuretics:hydrochlorothiazide,furosemide Beta-blockers Vasodilators O TONG UNI Others
Drugs used in CHF Drugs used in CHF Cardiac glycosides: digoxin, cedilanide RAS inhibitors: Diuretics: hydrochlorothiazide, furosemide Beta-blockers Vasodilators Others
上浒充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Section 1:RAAS inhibitors ACE Inhibitors in Heart Failure angiotensinogen blood renin normal kidney hypertension pressure angiotensin I plasma myocardial volume angiotensin converting dysfunction, moderate enzyme(ACE) myocardial angiotensin ll dysfunction, aldosterone severe OUTFLOW RESISTANCE adrenal gland blood vasoconstriction pressure
Section 1: RAAS inhibitors Section 1: RAAS inhibitors ACE Inhibitors in Heart Failure ACE Inhibitors in Heart Failure