上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 漏 Histamine &H-R blocking drugs A八VGHA7 IAOTON CH2-CH2一NH HN
Histamine &H-R blocking drugs
上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 introduction Histamine is widely distributed in body tissues;its functions as a neurotransmitter and neuromodulator. histidine histamine c00- storage mast cell and basophils allergy、 stimulate NO TONG release histamine◆H-R
introduction Histamine is widely distributed in body tissues; its functions as a neurotransmitter and neuromodulator. histidine coohistamine storage mast cell and basophils allergy、 stimulate release histamine H-R
上游充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 H-R distributing and effects type tissue effect antagonist H SM(bronchial,GI...) （+) diphenhydramine, dermal vessel (+) promethazine... atria,A-V node conduction H2 parietal cell secretion个 cimetidine, vessel 1回() ranitidine... ventricle,SA node HR个 H3 central and peripheral feedback thioperamide nerves regulation
H-R distributing and effects type tissue effect antagonist H1 SM (bronchial,GI…) (+) diphenhydramine, dermal vessel (+) promethazine… atria, A-V node conduction H2 parietal cell secretion cimetidine, vessel (-) ranitidine… ventricle, SA node HR H3 central and peripheral feedback thioperamide nerves regulation
上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Effects of Histamine 1.Cardiovascular system: 1)Cardiac effects:increased contractility and increased pacemaker rate.-mediated chiefly by H2-R. But H-R mediates the decrease of conductility in human atrial muscle. 2)Vascular effects:vasodilator action (H-R,H2-R). endothelial cells contraction and increased permeability (H-R)
Effects of Histamine 1. Cardiovascular system: 1) Cardiac effects: increased contractility and increased pacemaker rate.——mediated chiefly by H2 -R. But H1 -R mediates the decrease of conductility in human atrial muscle. 2) Vascular effects: vasodilator action ( H1 -R, H2 -R). endothelial cells contraction and increased permeability ( H1 -R)
上降充通大粤 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Effects of Histamine 2.Nervous system: powerful stimulant of sensory nerve endings,especially those mediating pain and itching. 3.Smooth muscle: contraction (H1-R)-bronchoconstriction,abort 4.Secretory tissues: stimulant of gastric acid secretion(H2-R) 5.The“triple response”: Intradermal injection of histamine causes a characteristic wheal-and-flare response
Effects of Histamine 2. Nervous system: powerful stimulant of sensory nerve endings, especially those mediating pain and itching. 3. Smooth muscle: contraction (H1-R) → bronchoconstriction, abort. 4. Secretory tissues: stimulant of gastric acid secretion (H2 -R) 5. The “triple response”: Intradermal injection of histamine causes a characteristic wheal-and-flare response