Chapter 24: Autacoid drugs Prof.R.D.Ye 2012-11-14
Chapter 24: Autacoid Drugs Prof. R.D. Ye 2012-11-14
Autacoid Drugs Autacoids are biological factors made in the body that act like "local hormones",have a brief duration,act near the site of synthesis (paracrine),and are not blood borne. Autacoids are regulating molecules metabolized locally. These factors can have many different biological actions
Autacoid Drugs • Autacoids are biological factors made in the body that act like “local hormones”, have a brief duration, act near the site of synthesis (paracrine), and are not blood borne. • Autacoids are regulating molecules metabolized locally. • These factors can have many different biological actions
Route of drug administration Drugs'Administration routes Buccal Per-Muccous Caval Venous tract then Pulmonary Bronchial Pulmonary route Portal venous tract Rectal venous route
Route of drug administration
Paracrine (left)and autocrine(right) (B)PARACRINE signaling cell target ● cells local mediator IN A GROUP OF IDENTICAL SIGNALING CELLS,EACH CELL RECEIVES A STRONG AUTOCRINE SIGNAL
Paracrine (left) and autocrine (right)
Major autacoids Arachidonic acid metabolites including: prostaglandins,thromboxanes,leukotrienes 5-hydroxytryptamine,5-HT,also named serotonin ·Bradykinin ·Endothelin ·Substance P
Major autacoids • Arachidonic acid metabolites including： prostaglandins, thromboxanes, leukotrienes • 5-hydroxytryptamine, 5-HT,also named serotonin • Bradykinin • Endothelin • Substance P