® 上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 漏 Antipyretic-analgesic and anti-inflammatory drugs (nonsteroidal anti-inflammatory drugs,NSAIDs) UALAO TONG UNIVEDSK MAAA
Antipyretic-analgesic and anti-inflammatory drugs (nonsteroidal anti-inflammatory drugs,NSAIDs)
上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Non-steroidal anti-inflammatory drugs (NSAIDs) NSAIDs have three major actions,all of which are due mainly to the inhibition of arachidonic acid cyclo-oxygenase in inflammatory cells (the COX-2 isoenzyme), and the resultant decrease in prostanoid synthesis. AJIAO TONG U
Non-steroidal anti-inflammatory drugs (NSAIDs) NSAIDs have three major actions, all of which are due mainly to the inhibition of arachidonic acid cyclo-oxygenase in inflammatory cells (the COX-2 isoenzyme), and the resultant decrease in prostanoid synthesis
上降充通大警 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Common Pharmacological Effects to be covered below Analgesic (CNS and peripheral effect)may involve non-PG related effects Antipyretic (CNS effect) Anti-inflammatory (except acetaminophen)due mainly to PG inhibition. Some shown to inhibit activation,aggregation,adhesion of neutrophils release of lysosomal enzymes Some are Uricosuric
Common Pharmacological Effects to be covered below • Analgesic (CNS and peripheral effect) may involve non-PG related effects • Antipyretic (CNS effect) • Anti-inflammatory (except acetaminophen) due mainly to PG inhibition. Some shown to inhibit activation, aggregation, adhesion of neutrophils & release of lysosomal enzymes • Some are Uricosuric
上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 COX: COX-1:constitutive enzyme:is involved in tissue homeostasis. COX-2:inducible enzyme:is responsible for the production of the prostanoid mediators of inflammation. VG JIAO TONG UNIVERSI 1三三5
• COX: • COX-1: constitutive enzyme: is involved in tissue homeostasis. • COX-2: inducible enzyme: is responsible for the production of the prostanoid mediators of inflammation
上浒充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 COX1 and COX2 Figure 3:The Current COX concept Arachidonic Acid Cytokines IL-1,TNF Growth factors C0X-1 C0X-2 Glucocorticoids Constitutive Induced Cytokines IL-4 1三 Inhibition Inhibition undesirable desirable Homeostatic functions Inflammation Gastrointestinal tract IAO Renal tract Platelet Function Macrophage differentiation
• COX1 and COX2