® 上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Agents used in blood nT ANGHA是IAO TON 1三
Agents used in blood
上游充通大淫 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Classification of drugs ●Anticoagulants ----Heparin,low molecular weight heparin ----Warfarin ● Fibrinolytics ●Antipletelet drugs Treatment of bleeding ----Vitamin K 1三三 Treatment of anemia ----Iron MA ----Cyanocobalamin (B12) ----Folic acid
●Anticoagulants ----Heparin, low molecular weight heparin ----Warfarin ● Fibrinolytics ● Antipletelet drugs ● Treatment of bleeding ----Vitamin K ● Treatment of anemia ----Iron ----Cyanocobalamin (B12) ----Folic acid Classification of drugs
上浒充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Physiological hemostasis Damaged vessel Damaged endothelium Activated clotting vasospasm Platelet factors aggregation Platelet plug solid fibrin clot formed ONG Arrest bleeding
Physiological hemostasis Damaged vessel vasospasm Activated clotting factors solid fibrin clot formed Platelet plug Arrest bleeding Platelet aggregation Damaged endothelium - -
上济充通大学 SHANGHAI IIAO TONG UNIVERSITY 1896 1920 1987 2006 Mechanism of Blood Coagulation Intrinsic pathway Extrinsic pathway Collagen or other Damage exposes activators tissue factor(Ill) Active XII Tissue factor Ca2+ (Ill)and Active active Vll XI Ca2+ positive feedback Active X VIn Ca2+,PL X Active X Common pathway Ca2+,V,PL ---------positive feedback------------ Thrombin Prothrombin PL=phospholipids Fibrinogen Fibrin XI Active X☒1Ⅲ Cross-linked fibrin
Mechanism of Blood Coagulation Mechanism of Blood Coagulation
上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Factor Xa 。Factor Xa is an Land Dwelling Vertebrates attractive target for the Tissue factor Surfaces (eg collagen) ↓ design of new oral VII X anticoagulants because of the unique role factor Xa plays in IXa IX LVIlla the coagulation Xa cascade as a II(prothrombin) ◆Ila(Thrombin connection between the extrinsic and AO ibrinogen◆Fibrin)◆Stabilised Fibrin intrinsic pathways
Factor Xa • Factor Xa is an attractive target for the design of new oral anticoagulants because of the unique role factor Xa plays in the coagulation cascade as a connection between the extrinsic and intrinsic pathways