Drug classification Antipsychotics:chlorpromazine,... Antimanic drugs:lithium carbonate Antidepressants mood-elevating drugs):fluoxetine,... Antianxiety agents mood-stabilizing drugs):diazepam,…
Drug classification Antipsychotics ：chlorpromazine,… Antimanic drugs ：lithium carbonate Antidepressants （mood-elevating drugs）：fluoxetine,… Antianxiety agents （mood-stabilizing drugs）：diazepam,…
Antipsychotic drugs Schizophrenia:mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. Etiology: Genetic cause +eg,influenza during pregnancy;hypoxia at birth ++social and/or psychological causes =unstable function of the brain and/or deficiency of brain structure
Antipsychotic drugs Schizophrenia： mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. Etiology: Genetic cause ＋eg, influenza during pregnancy; hypoxia at birth ＋social and/or psychological causes ＝unstable function of the brain and/or deficiency of brain structure
Etiology of schizophrenia (cont.) Homozygous twin,40%~50% Parent-offspring:10%; Common population:1%worldwide 80%genetic trend (gene therapy?) Many genes cloned:RGS4,DISC1, dysbindin,neuregulin,G72,CHRNA7, COMT,PRODH,.（贺林院士较多贡献！) Genes environmental/psychological factors
Etiology of schizophrenia (cont.) Homozygous twin ，40％～50 ％ Parent-offspring ：10 ％; Common population ： 1 ％worldwide 80 ％genetic trend (gene therapy?) Many genes cloned ：RGS4, DISC1, dysbindin, neuregulin, G72, CHRNA7, COMT, PRODH, …（贺林院士较多贡献 ! ） Genes ＋environmental/psychological factors
Clinical manifestations > Delusion(妄想)：greatness,lovingness, delusion of being killed,.. >lllusion(幻觉)：auditory hallucination >Disordered thought: 医生：你好吗？ 病人：我不是坏人。 病人：（见医生着红毛衣）红色代表革命，白色 代表反革命。所以我不吃白米饭，要吃的话，我吃红 米饭。 Disordered emotion:illogical psychological responses to outside stimulations > Bizarre(怪诞)：eating anything,untidiness, unconscious action
Delusion(妄想)：greatness, lovingness, delusion of being killed, … Illusion(幻觉)：auditory hallucination Disordered thought： 医生：你好吗？ 病人：我不是坏人。 病人：（见医生着红毛衣）红色代表革命，白色 代表反革命。所以我不吃白米饭，要吃的话，我吃红 米饭。 Disordered emotion: illogical psychological responses to outside stimulations Bizarre（怪诞） ：eating anything, untidiness, unconscious action, … Clinical manifestations
Therapeutic story Before 1800's,locked by iron chain 1933,insulin shock 1934,pentetrazole-induced convulsion 1937，electroconvulsive treatment electrodes on temporals,100-140 volt, 0.3-0.6 s-transient loss of consciousness and general convulsion ●1950，chlorpromazine (氯丙嗪)
Before 1800’s, locked by iron chain 1933, insulin shock 1934, pentetrazole-induced convulsion 1937, electroconvulsive treatment electrodes on temporals， 100－140 volt， 0.3-0.6 s→transient loss of consciousness and general convulsion 1950, chlorpromazine （氯丙嗪） Therapeutic story