Classifications Benzodiazepines(Bz,苯二氮草类) Barbiturates(巴比妥类) I Others some are popular
6 ▪ Benzodiazepines (BZ，苯二氮卓类): ▪ Barbiturates (巴比妥类) ▪ Others some are popular Classifications
haracteristics ch 1. Graded dose-dependent depression of cNs function Coma g Anesthesia 000z0 Drug B enosIs Sedation Increasing dose Dose-response curves for two hypothetical sedative-hypnotics Drug A: barbiturates Drug B: benzodiazepines and certain newer hypnotics
7 1. Graded dose-dependent depression of CNS function Characteristics Dose-response curves for two hypothetical sedative-hypnotics Drug A: barbiturates Drug B: benzodiazepines and certain newer hypnotics
Ratio of lethal dose to effective dose for phenobarbital and diazepam Benzodiazepines are relativel safe, because the lethal dose is over 1000-fold greater than the typical therapeutic dose. Phenobarbital Diazepam 02040 1000 Ratio Lethal dose Effective dose
8 Ratio of lethal dose to effective dose for phenobarbital and diazepam
2. Different influences on sleep phases 3. Tolerance 4. Dependence Physiological dependence withdrawal symptoms Psychological dependence
9 *2. Different influences on sleep phases 3. Tolerance 4. Dependence Physiological dependence withdrawal symptoms Psychological dependence
Phases of sleep 1. NREMS( non rapid eye movement sleep,非快动眼睡眠) sWs( slow wave sleep,慢波睡眠) Stages1-4(入睡期、浅睡期、中度睡眠期、深度睡眠期) Characterists. Play roles in eliminating the fatigue and promote growth night-waking(夜惊), sleep-walking(梦游, somnambu|ism) occur in stage 3 and 4 y shorten stage 3 and 4 will clean up night-waking and sleep-walking 10
10 ➢ Play roles in eliminating the fatigue and promote growth ➢ night-waking（夜惊）, sleep-walking（梦游, somnambulism） occur in stage 3 and 4 SWS ( slow wave sleep，慢波睡眠) ➢ shorten stage 3 and 4 will clean up night-waking and sleep-walking. Characterists: Stages 1- 4 (入睡期、浅睡期、中度睡眠期、深度睡眠期) 1. NREMS (non rapid eye movement sleep, 非快动眼睡眠) Phases of sleep