INTRODUCTION-methylatedMGMTTumorwith methylated MGMT(inactive gene)have been found to predict a longer length ofsurvival,andrespondsbettertochemotherapeutic agents in the treatment ofglioblastoma蘇北人民医院
• Tumor with methylated MGMT (inactive gene) have been found to predict a longer length of survival, and responds better to chemotherapeutic agents in the treatment of glioblastoma
INTRODUCTION--IDH1mutationThe IDH1mutationwas discovered ina small percentageof glioblastoma samples,but majority oflow-grade gliomasandsecondaryhigh-gradegliomasThis mutationwas present in 12%of GBM.These markersare beginning to be used as a diagnostic test for predictinglonger survival andforevaluating theefficacyof newtargetedmoleculardrugsIDH1mutationsmay serveasapredictivebiomarker toguide aggressive surgical resection.Patients withIDH1-mutant glioma were found to have a better overallprognosis thanthosewithwild-type IDH1glioma蘇北人民医院
• The IDH1 mutation was discovered in a small percentage of glioblastoma samples, but majority of low-grade gliomas and secondary high-grade gliomas. • This mutation was present in 12% of GBM. These markers are beginning to be used as a diagnostic test for predicting longer survival and for evaluating the efficacy of new targeted molecular drugs. • IDH1 mutations may serve as a predictive biomarker to guide aggressive surgical resection. Patients with IDH1- mutant glioma were found to have a better overall prognosis than those with wild-type IDH1 glioma
蘇北人民医院CAUSEBrain tumors cannot be prevented. The cause ofthese tumors and other types of brain tumors isunknownScientists have identified abnormalities in the genes ofdifferent chromosomes which may play a role inthedevelopment of tumors. However, what causes thoseabnormalities is still uncertain.Scientists are conducting environmental,occupationalfamilial and genetic research to identify common linksamong patients. Despite a great deal of research onenvironmental hazards, no direct causes have beenfound.The majority of brain tumors are not hereditary
⚫ Brain tumors cannot be prevented. The cause of these tumors and other types of brain tumors is unknown ⚫ Scientists have identified abnormalities in the genes of different chromosomes which may play a role in the development of tumors. However, what causes those abnormalities is still uncertain. ⚫ Scientists are conducting environmental, occupational, familial and genetic research to identify common links among patients. Despite a great deal of research on environmental hazards, no direct causes have been found. ⚫ The majority of brain tumors are not hereditary
蘇北人民医院How do braintumorsCause problems?·Masseffect·Tumor pusheson normal brainLocalinvasion.Tumorsinvade normal brain·MicroscopicEdema·Swelling of normal brain
FRONTALLOBEPARIETALLOBEOCCIPITALMovementLOBESensationSensory PerceptionSpatial RelationsHearingThoughtReasoningLeft:Speech,Motion,SensationBehaviorRight:AbstractConceptsMemoryBehavior(ForRight-HandedIndividuals)MemoryVisionHearing & Vision PathwaysEmotionPONSTEMPORAL LOBECEREBELLUMBalance CoordinationMEDULLAAsabraintumorgrows,itmayinterferewiththenormal functionsofthe brain.Symptomsareanoutwardsignofthisinterference