本科生《药物设计学》专业课 筛选途径的药物发现 Screening Based Drug Discovery 复旦大学药学院药物化学教研室 李炜 wei-li@fudan.edu.cn
筛选途径的药物发现 Screening Based Drug Discovery 复旦大学药学院药物化学教研室 李 炜 wei-li@fudan.edu.cn 本科生《药物设计学》专业课
Janssen PHARMACEUTICAL COMPANIES Paul Janssen(1926-2003)
Paul Janssen (1926-2003)
New medicines discovered by Janssen’ s tean OH N N H2c N haloperidol fentanyl NCH 3 N(CH3)2 N HO F CI risperidone loperamide More than 80 new medicines(absolute world record), at the wide range of his inventions in psychopharmacology, neuropharmacology, gastroenterology, cardiology, parasitology, virology, immunology, anaesthesiology, and analgesia
New medicines discovered by Janssen’s team haloperidol risperidone fentanyl loperamide More than 80 new medicines (absolute world record), at the wide range of his inventions in psychopharmacology, neuropharmacology, gastroenterology, cardiology, parasitology, virology, immunology, anaesthesiology, and analgesia
Classic of Phenotypic screening Iterative evolution process Conception A lead compd Test feedback A picture of Appropriate Synthesis Bioassay structure- bioassay Unmet evaluation activit relationship medical need Active in least 3 /5 authentic exovivo or in vivo pharmacological models When Fit for its purpose? Judgment Experience Workup Creativity Imagination Aesthetic intuition -A concept-driven project
Classic of Phenotypic screening Conception A lead compd Appropriate bioassay Unmet medical need Iterative evolution process Synthesis Bioassay evaluation Test feedback A picture of structureactivity relationship Active in least 3/5 authentic exo-vivo or in vivo pharmacological models When Fit for its purpose? Judgment Experience Imagination Aesthetic intuition —— A concept-driven project Workup Creativity When Fit for its purpose? Judgment Experience Imagination Aesthetic intuition
Real-world Screening based Drug discovery 天然 成 药物化学家 微生 药理学家 物 先导化合物 Main concerns DIVERSITY THROUGHPUT TRANSLATION
Real-world Screening based Drug discovery 药物化学家 药理学家 先导化合物 微生 物 天然 产物 合成 Main concerns DIVERSITY THROUGHPUT TRANSLATION