Epoprostenol Prostacyclin (or PGI2),as a drug,is known as "epoprostenol".The terms are sometimes used interchangeably. H Prostacyclin(PGI2)chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation).It does this by inhibiting platelet activation.It is also an effective vasodilator.Prostacyclin's interactions in contrast to thromboxane(TXA2),another eicosanoid,strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage. HO
Epoprostenol Prostacyclin (or PGI2), as a drug, is known as "epoprostenol". The terms are sometimes used interchangeably. Prostacyclin (PGI2) chiefly prevents formation of the platelet plug involved in primary hemostasis (a part of blood clot formation). It does this by inhibiting platelet activation. It is also an effective vasodilator. Prostacyclin's interactions in contrast to thromboxane (TXA2), another eicosanoid, strongly suggest a mechanism of cardiovascular homeostasis between the two hormones in relation to vascular damage
Misoprostol Pharmacologically,misoprostol is a synthetic prostaglandin E1(PGE1)analogue. Misoprostol is a drug that is used for the prevention of non-steroidal anti- inflammatory drug(NSAID)induced gastric ulcers,for early abortion,to treat missed miscarriage,and to induce labor.The latter use is controversial in the United States.Misoprostol was invented and marketed by G.D.Searle Company (now Pfizer)under the trade name Cytotec
Misoprostol Pharmacologically, misoprostol is a synthetic prostaglandin E1 (PGE1) analogue. Misoprostol is a drug that is used for the prevention of non-steroidal antiinflammatory drug (NSAID) induced gastric ulcers, for early abortion, to treat missed miscarriage, and to induce labor. The latter use is controversial in the United States. Misoprostol was invented and marketed by G.D. Searle & Company (now Pfizer) under the trade name Cytotec
Dinoprostone,PGE2 OH HO ōH The naturally occurring prostaglandin E2(PGE2)is known in medicine as dinoprostone.It has important effects in labor(softens cervix and causes uterine contraction)and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts.PGE2 is also the prostaglandin that ultimately induces fever
Dinoprostone, PGE2 The naturally occurring prostaglandin E2 (PGE2) is known in medicine as dinoprostone. It has important effects in labor (softens cervix and causes uterine contraction) and also stimulates osteoblasts to release factors that stimulate bone resorption by osteoclasts. PGE2 is also the prostaglandin that ultimately induces fever
Carboprost,PGF2a HO HO OH Carboprost is a synthetic prostaglandin analogue of PGF2 a(specifically,it is 15- methyl-PGF2 a with oxytocic properties. Carboprost induces contractions and can trigger abortion in early pregnancy.It also reduces postpartum bleeding
Carboprost, PGF2 Carboprost is a synthetic prostaglandin analogue of PGF2α (specifically, it is 15- methyl-PGF2α) with oxytocic properties. Carboprost induces contractions and can trigger abortion in early pregnancy. It also reduces postpartum bleeding
Synthesis and inhibition of leukotrienes Antigens Leukocyte Cold air Exercise LTE Target cells Cytokines CysLT1 Smooth muscle Endothelial cells Phospholipids LTD4 Goblet cells Leukocytes PLA2 LTC- Zileuton Montelukast Zafirlukast Sg→tcat2 Arachidonic 5-lipoxygenase Biologic LTA effects acid Gi→CAMP LTB4- Transporter BLT1 Inhibition at the 5-LOX level and at the receptor level
Synthesis and inhibition of leukotrienes Inhibition at the 5-LOX level and at the receptor level