Cancer Chemotherapy Li Xinyan 20121219
Cancer Chemotherapy Li Xinyan 20121219
General Introduction Mechanisms of Chemotherapy Drugs Principles of combination therapies o Classification of Chemotherapy Drugs Toxicity of Chemotherapy Drugs Some Examples for Cancer Chemotherapy
• General Introduction • Mechanisms of Chemotherapy Drugs • Principles of combination therapies • Classification of Chemotherapy Drugs • Toxicity of Chemotherapy Drugs • Some Examples for Cancer Chemotherapy
General Introduction Malignant disease needs a multidisciplinary approach In addition to surgery,radiotherapy and chemotherapy, attention to psychiatric and social factors is also essential. In some cases,chemotherapy is given following surgery in the knowledge that widespread microscopic dissemination almost certainly has occurred (this is termed 'adjuvant chemotherapy'). If the tumour is widespread at presentation,systemic chemotherapy is more likely to be effective than radiotherapy or surgery,although these may be used to control local disease or reduce the tumour burden before potentially curative chemotherapy
• Malignant disease needs a multidisciplinary approach. In addition to surgery, radiotherapy and chemotherapy, attention to psychiatric and social factors is also essential. • In some cases, chemotherapy is given following surgery in the knowledge that widespread microscopic dissemination almost certainly has occurred (this is termed ‘adjuvant chemotherapy’). • If the tumour is widespread at presentation, systemic chemotherapy is more likely to be effective than radiotherapy or surgery, although these may be used to control local disease or reduce the tumour burden before potentially curative chemotherapy. General Introduction
What is Chemotherapy 。 Chemotherapy is the Chemotherapy use of drugs to inhibit Cancer cells or kill proliferating Normal cells cancer cells,while leaving host cells unharmed,or at least recoverable. 1996-2003 WebMD,Inc.All rights reserved, http://www.wwu.edu/depts/healthyliving/PE5 11info/cancer/My%20Cancer%20Webs/Sympt oms%20and%20Therapy_files/image001.jpg
What is Chemotherapy ? • Chemotherapy is the use of drugs to inhibit or kill proliferating cancer cells, while leaving host cells unharmed, or at least recoverable. http://www.wwu.edu/depts/healthyliving/PE5 11info/cancer/My%20Cancer%20Webs/Sympt oms%20and%20Therapy_files/image001.jpg
Acquired(environmental) NORMAL CELL DNA damaging agents: Cellular ◆chemicals Successful radiation DNA repair Pathways to ·viruses DNA Damage Malignancy Failure of Inherited mutations in: DNA repair Genes affecting DNA repair Mutations in the ·Genes affecting cell genome of growth or apoptosis somatic cells Activation of Alterations of Inactivation of growth-promoting genes that cancer suppressor oncogenes regulate apoptosis genes Expression of altered gene products and loss of regulatory gene products Clonal expansion Additional mutations (progression) Heterogeneity Malignant neoplasm
Cellular Cellular Pathways Pathwaysto Malignancy Malignancy