Chapter 19,part B Disorders Associated with the Immune System
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings B.E Pruitt & Jane J. Stein Chapter 19, part B Disorders Associated with the Immune System
Acquired Immunodeficiency Syndrome (AIDS) 。1981 In U.S.,cluster of Pneumocystis and Kaposi's sarcoma in young homosexual men discovered.The men showed loss of immune function. 。1983 Discovery of virus causing loss of immune function
Acquired Immunodeficiency Syndrome (AIDS) • 1981 In U.S., cluster of Pneumocystis and Kaposi's sarcoma in young homosexual men discovered. The men showed loss of immune function. • 1983 Discovery of virus causing loss of immune function
Acquired Immunodeficiency Syndrome (AIDS) 9p120 RNA Reverse transcriptase enzyme Core with protein coat Capsomeres of protein coat Envelope (a)Structure of HIV Figure 19.12a
Acquired Immunodeficiency Syndrome (AIDS) Figure 19.12a
The Origin of AIDS Crossed the species barrier into humans in Africa in the 1930s Patient who died in 1959 in Congo is the oldest known case Spread in Africa as a result of urbanization Spread in world through modern transportation and unsafe sexual practices Norwegian sailor who died in 1976 is the first known case in Western world
• Crossed the species barrier into humans in Africa in the 1930s • Patient who died in 1959 in Congo is the oldest known case • Spread in Africa as a result of urbanization • Spread in world through modern transportation and unsafe sexual practices • Norwegian sailor who died in 1976 is the first known case in Western world The Origin of AIDS
HIV Infection 89分 CD4 receptor CXCR4 coreceptor T cell DNA (b)HIV infecting a T cell with CD4 receptors, and CXCR4 coreceptors which are distributed over the surface of the cell Figure 19.12b
HIV Infection Figure 19.12b