TORTORA·FUNKE·CASE Microbiology AN INTRODUCTION EIGHTH EDITION Chapter 19,part A Disorders Associated with the Immune System
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings Microbiology B.E Pruitt & Jane J. Stein AN INTRODUCTION EIGHTH EDITION TORTORA • FUNKE • CASE Chapter 19, part A Disorders Associated with the Immune System
Disorders Associated with the Immune System Infection and immunosuppression are failures of the immune system. Superantigens cause release of cytokines that cause adverse host responses. Allergies and transplant rejection are harmful immune reactions
Disorders Associated with the Immune System • Infection and immunosuppression are failures of the immune system. • Superantigens cause release of cytokines that cause adverse host responses. • Allergies and transplant rejection are harmful immune reactions
Hypersensitivity Reactions Response to antigens (allergens)leading to damage Require sensitizing dose(s)
• Response to antigens (allergens) leading to damage • Require sensitizing dose(s) Hypersensitivity Reactions
Type I (Anaphylactic)Reactions 。Involve IgE antibodies 。Localized:Hives Mast cell or Granule or asthma from basophil contact or inhaled antigens Systemic:Shock Histamine and IgE leukotrienes from ingested or Antigen E洲 injected antigens Figure 19.la
• Involve IgE antibodies • Localized: Hives or asthma from contact or inhaled antigens • Systemic: Shock from ingested or injected antigens Type I (Anaphylactic) Reactions Figure 19.1a
Type I (Anaphylactic)Reactions 。 Skin testing 。Desensitization Figure 19.3
• Skin testing • Desensitization Type I (Anaphylactic) Reactions Figure 19.3