Chapter 20,part B Antimicrobial Drugs
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings B.E Pruitt & Jane J. Stein Chapter 20, part B Antimicrobial Drugs
Antifungal Drugs Inhibition of Ergosterol Synthesis 。Polyenes ·Amphotericin B 。Azoles N C CH2 CI 。Miconazole 。Triazoles c- CH2-O-CH- 。Allylamines Miconazole Figure 20.15
• Polyenes • Amphotericin B • Azoles • Miconazole • Triazoles • Allylamines Antifungal Drugs Inhibition of Ergosterol Synthesis Figure 20.15
Antifungal Drugs Inhibition of Cell Wall Synthesis 。Echinocandins Inhibit synthesis of B-glucan Cancidas is used against Candida and Pneumocystis
• Echinocandins • Inhibit synthesis of -glucan • Cancidas is used against Candida and Pneumocystis Antifungal Drugs Inhibition of Cell Wall Synthesis
Antifungal Drugs Inhibition of Nucleic Acids 。Flucytocine Cytosine analog interferes with RNA synthesis Pentamidine isethionate Anti-Pneumocystis;may bind DNA
• Flucytocine • Cytosine analog interferes with RNA synthesis • Pentamidine isethionate • Anti-Pneumocystis; may bind DNA Antifungal Drugs Inhibition of Nucleic Acids
Antifungal Drugs Inhibition of Microtubules (Mitosis) 。Griseofulvin Used for superficial mycoses 。Tolnaftate Used for athlete's foot:action unknown
• Griseofulvin • Used for superficial mycoses • Tolnaftate • Used for athlete's foot; action unknown Antifungal Drugs Inhibition of Microtubules (Mitosis)