Drugs used in asthma Bronchodilators Anti-inflammatory agents Leukotriene antagonists Beta Release Lipoxygenase Receptor agonists inhibitors inhibitors inhibitors Muscarinic Steroids Antibodies antagonists Slow anti-inflam- Methylxanthines matory drugs Drugs used in chroni nic obstructive pulmonary disease Bronchodilators Anti-inflammatory agents Antibiotics Steroids
Bronchodilators aβ Receptor agonists D Non-selective: adrenaline, isoprenaline 囗β- selective: salbutamol, terbutaline, salmeterol formoterol D Theophyllines: aminophylline o Muscarinic antagonists: ipratropium bromide
Bronchodilators Receptor agonists Non-selective：adrenaline, isoprenaline 2-selective: salbutamol, terbutaline, salmeterol, formoterol Theophyllines: aminophylline Muscarinic antagonists: ipratropium bromide
ATP Bronchodilation Beta agonists CAMP Bronchial tone PDE Theophylline AMP Acetylcholine +aDenosine Muscarinic antagonists Theophy lline Bronchoconstriction
β receptor agonists HO -CHCH2-NH2 NOREPINEPHRINE non-selectivity HO OH 去甲肾上腺素 HO CH-CH2NH EPINEPHRINE 肾上腺素 HO OH CHa CHCH2-NH ISOPROTERENOL HO OH 异丙肾上腺素 CH(CHak JOH2C ALBUTEROLOL H-CH2-NH o B2 receptor selective agonists HO HOH2C CH-CH2NHCH2 (CH)s-OCH2( CH2)3 SALMETEROL 沙丁胺醇 HO FORMOTEROL HCONH FCH2NHCH-CH2 OCH3 福莫特罗 HO
receptor agonists 去甲肾上腺素 异丙肾上腺素 沙丁胺醇 福莫特罗 肾上腺素 non-selectivity 2 receptor selective agonists
B, agonist R1 cc—NH Iberiotoxin colr membran ATP GTP G UV Cyclic AMP ↑ca2· activated K' channel activation Methylxanthines PDE +PLC- IPa Ca pathway activity ↑PKA ↑Na’Ca2 exchange 5AMP ↑Na+ca2ATPa ↓MLcK