Increase in effective surface area of drug exposed to gastrointestinal fluids Disintegration Deaggregation Intact tablet 。品3.88 Granules Primary drug particles Moderate rate Relatively rapid rate of drug drug dissolution dissolution fluids ↓ Absorption ↓ Drug in blood
Method of disintegrants addition Intragranular:addition of disintegrant before wet granulation. -Assist in the breakup of the pieces into fine particles. Extragranular:addition of disintegrant after the granulation process. Assist in the breakup of the tablet into pieces. o Dividing the disintegrant into both extra-and intragranular portions,with between 25 and 50% being external
Method of disintegrants addition • Intragranular: addition of disintegrant before wet granulation. – Assist in the breakup of the pieces into fine particles. • Extragranular: addition of disintegrant after the granulation process. – Assist in the breakup of the tablet into pieces. • Dividing the disintegrant into both extra- and intragranular portions, with between 25 and 50% being external
Commonly used disintegrants ·Dry starch Carboxymethyl starch sodium,(CMS-Na,羧甲基 淀粉钠 L-Hydroxypropylcellulose,.L-HPC(低取代羟丙 基纤维素) Cross-linked polyvinyl pyrrolidone(交联聚乙k烯 吡咯烷酮) Croscarmellose sodium(CCMC-Na,交联羧甲基 纤维素钠) Effervescent disintegrants
Commonly used disintegrants • Dry starch • Carboxymethyl starch sodium，(CMS-Na,羧甲基 淀粉钠) • L-Hydroxypropylcellulose，L-HPC(低取代羟丙 基纤维素 ) • Cross-linked polyvinyl pyrrolidone (交联聚乙烯 吡咯烷酮) • Croscarmellose sodium (CCMC-Na,交联羧甲基 纤维素钠) • Effervescent disintegrants
Dry starch Water content less than 8%.they are dried at l00℃before being used Swelling efficiency:78% Can be used as disintegrants for water- insoluble or slightly water-soluble substance's tablets
Dry starch • Water content less than 8%. they are dried at 100℃ before being used • Swelling efficiency: 78% • Can be used as disintegrants for waterinsoluble or slightly water-soluble substance’s tablets
Carboxymethyl starch sodium (CMS-Na) Swell up to 200-300 times of its volume in water. 。Using amount:4-8% Commercial name:Primojel
Carboxymethyl starch sodium (CMS-Na) • Swell up to 200-300 times of its volume in water. • Using amount: 4-8% • Commercial name: Primojel