Section 4.Tablets
Section 4. Tablets
Overview >Introduction >Commonly used excipients >Preparation of tablets >Tablet coatings >Tablet quality control
Overview ➢Introduction ➢Commonly used excipients ➢Preparation of tablets ➢Tablet coatings ➢Tablet quality control
Introductions Definitions:tablets may be defined as unit forms of solid medicaments prepared by compaction. Tablets are the most common dosage form. low cost of manufacture,package,shipment, increased stability,virtual tamper resistance self-administered more profitable to manufacture than parenteral dosage form The most common types of tablets are those intended to be swallowed whole and then disintegrate and release their medicaments in the gastrointestinal tract (GIT). These medicinal substances include extracts of medicinal substances and fine powder of medicinal substances
Introductions • Definitions: tablets may be defined as unit forms of solid medicaments prepared by compaction. • Tablets are the most common dosage form. - low cost of manufacture，package，shipment， increased stability，virtual tamper resistance - self-administered ，more profitable to manufacture than parenteral dosage form • The most common types of tablets are those intended to be swallowed whole and then disintegrate and release their medicaments in the gastrointestinal tract (GIT). • These medicinal substances include extracts of medicinal substances and fine powder of medicinal substances
Types of Tablets 。Compressed tablets Coated tablets Sugar coated -Film Coated:Most popular coating method. Enteric Coated Chewable tablets:is often used when absorption from the buccal cavity is desired or to enhance dispersion prior to swallowing.For example:Multivitamins,Vitamin C Chewable Tablets. Effervescent:their main advantages include rapid release of drug and minimization of gastric irritation
Types of Tablets • Compressed tablets • Coated tablets – Sugar coated – Film Coated: Most popular coating method. – Enteric Coated • Chewable tablets: is often used when absorption from the buccal cavity is desired or to enhance dispersion prior to swallowing. For example:Multivitamins, Vitamin C Chewable Tablets. • Effervescent: their main advantages include rapid release of drug and minimization of gastric irritation
Types of Tablets (cont.) 。 Multilayered:mainly used for incompatible substances. Dispersible tablets:is formulated to allow dissolution or dispersion in water prior to administration. Sublingual:are designed to be placed under the tongue and rapidly release drug into the blood-stream. Often desirable Buccal tablets:are designed to be placed between the teeth for drugs and gum and rapidly release drug into the blood-stream. liable to Implant tablets:inserted into body tissues by surgical extensive procedures. hepatic Solution tablets:for this type of tablet all ingredients metabolism should be soluble. by the first- Sustained and controlled release tablets-to be covered in pass effect future lectures
Types of Tablets (cont.) • Multilayered: mainly used for incompatible substances. • Dispersible tablets: is formulated to allow dissolution or dispersion in water prior to administration. • Sublingual: are designed to be placed under the tongue and rapidly release drug into the blood-stream. • Buccal tablets: are designed to be placed between the teeth and gum and rapidly release drug into the blood-stream. • Implant tablets: inserted into body tissues by surgical procedures. • Solution tablets: for this type of tablet all ingredients should be soluble. • Sustained and controlled release tablets- to be covered in future lectures. Often desirable for drugs liable to extensive hepatic metabolism by the firstpass effect