Advantages of tablets It enables an accurate dosage of medicament to be administered simply. It is easy to transport in bulk and carry by the patient. Usually more stable than liquid preparations. The release rate of the drug from a tablet can be tailored to meet pharmacological requirements. Tablets can be mass produced simply and quickly and the resultant manufacturing cost is therefore very much lower when compared with other dosage forms. The dissolution and bioavailability of most tablets are better than those of pills
Advantages of tablets • It enables an accurate dosage of medicament to be administered simply. • It is easy to transport in bulk and carry by the patient. • Usually more stable than liquid preparations. • The release rate of the drug from a tablet can be tailored to meet pharmacological requirements. • Tablets can be mass produced simply and quickly and the resultant manufacturing cost is therefore very much lower when compared with other dosage forms. • The dissolution and bioavailability of most tablets are better than those of pills
Disadvantages of Tablets Swallowing:Children and comatose patients may not swallow tablets Volatile components in tablets may be lost during the long periods of storage Formulation difficulties: Some drugs have poor oral bioavailability or poor water solubility Some drugs have an irritant effect on the GI tract when taken orally
Disadvantages of Tablets • Swallowing:Children and comatose patients may not swallow tablets • Volatile components in tablets may be lost during the long periods of storage • Formulation difficulties: • Some drugs have poor oral bioavailability or poor water solubility • Some drugs have an irritant effect on the GI tract when taken orally
What is a good tablet?(Quality requirement) Appropriate hardness Appealing appearance 。Accurate dose Uniformity (weight,amount of active,coating thickness,etc.):especially for small dosage drugs Appropriate disintegration and dissolution Stability of the drug ("the active") Masking of taste,odour Production is economically sound
What is a good tablet? ( Quality requirement) • Appropriate hardness • Appealing appearance • Accurate dose • Uniformity (weight, amount of active, coating thickness, etc.): especially for small dosage drugs • Appropriate disintegration and dissolution • Stability of the drug ("the active") • Masking of taste, odour • Production is economically sound
Tablet excipients
Tablet excipients
Tablet excipients Definitions:Excipients are components of tablets that have a role other than the therapeutic effect. The International Pharmaceutical Excipients Council (IPEC)lists general categories of excipients: Fillers (diluents) Binders and moistening agents -Disintegrants Lubricants Flavoring agents Film formers -Printing inks Opacifiers
Tablet excipients • Definitions: Excipients are components of tablets that have a role other than the therapeutic effect. • The International Pharmaceutical Excipients Council (IPEC) lists general categories of excipients: – Fillers (diluents) – Binders and moistening agents – Disintegrants – Lubricants – Flavoring agents – Film formers – Printing inks – Opacifiers