Antiviral Drugs Nucleoside and Nucleotide Analogs 0 0 C- Guanine HN c一N HN C一N CH CH H2N-C-N C-N NN-CN一CN HOCH2 HOCH2 H H H HO H Deoxyguanosine Acyclovir (a)Structural resemblance between acyclovir and guanine-containing nucleoside Figure 20.16a
Antiviral Drugs Nucleoside and Nucleotide Analogs Figure 20.16a
Antiviral Drugs Nucleoside and Nucleotide Analogs Phosphate Host cell enzyme thymidine kinase MMNV Incorporated into DNA Guanine DNA polymerase nucleotide Nucleoside (b)Synthesis of normal viral DNA guanine nucleotide Phosphate Viral enzyme thymidine kinase DNA polymerase blocked by false nucleotide.Assembly False nucleotide of DNA stops. (acyclovir triphosphate) Acyclovir (c)Synthesis of false viral DNA nucleotide with acyclovir Figure 20.16b,c
Antiviral Drugs Nucleoside and Nucleotide Analogs Figure 20.16b, c