为 上游充通大学 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 Antihistamines H-R blocking drugs The first-generations has a relatively strong sedative effects Diphenhydramine Promethazine Tripelennamine TONG UNIVERSITY Chlorpheniramine ●●●●●●
H1 -R blocking drugs The first –generations has a relatively strong sedative effects Diphenhydramine Promethazine Tripelennamine Chlorpheniramine …… Antihistamines
上游充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 H-R blocking drugs The second-generations has less sedative effects and less distribution into the CNS Cetirizine≌ Pheniadamine Astemizole HAI J AO TONG UNIVERSITY V Terfenadine
H1 -R blocking drugs The second-generations has less sedative effects and less distribution into the CNS Cetirizine Pheniadamine Astemizole Terfenadine ……
上游充通大淫 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 H-R blocking drugs common characteristics] 1.the basic structures similar as histamine; -CH2-CH2-N< 2.their action mechanisms are same: competitive blocking H-R; 3.the characteristics of pharmacokinetics are similar: rapidly absorbed by po. metabolized primarily in the liver
H1 -R blocking drugs 【 common characteristics 】 1. the basic structures similar as histamine; -CH2 -CH2 -N 2. their action mechanisms are same: competitive blocking H1 -R; 3. the characteristics of pharmacokinetics are similar: rapidly absorbed by po. metabolized primarily in the liver
上浒充通大 SHANGHAI JIAO TONG UNIVERSITY 1896 1920 1987 2006 H-R blocking c drugs 【Actions and clinical uses】 1.H-R blockage the first used to prevent allergic reactions or treat their symptoms,such as rhinitis,urticaria etc. notice:(inefficiency)allergic shock and bronchial asthma 1 2.Central inhibitions prevention of motion sickness and vestibular disturbances,nausea and vomiting of pregnancy
H1 -R blocking drugs 【Actions and clinical uses】 1. H1 -R blockage the first used to prevent allergic reactions or treat their symptoms, such as rhinitis, urticaria etc. notice: (inefficiency) allergic shock and bronchial asthma 2. Central inhibitions prevention of motion sickness and vestibular disturbances , nausea and vomiting of pregnancy