Function To transport oxygen from the lungs to the tissue (function of hemoglobin) To transport carbon dioxide in blood Hb+40 Hb(O2)4 lobin Oxyhemoglobin The arterial and venous red cell 17
17 The arterial and venous red cell Function: ➢To transport oxygen from the lungs to the tissue (function of hemoglobin) ➢To transport carbon dioxide in blood
Material for the production The protein and iron are used for hemoglobin synthesis Both vitamin b12 and folic acid are necessary co-factors for DNA synthesis which is essential for maturation of the red cells 18
18 Material for the production. The protein and iron are used for hemoglobin synthesis. Both vitamin B12 and folic acid are necessary co-factors for DNA synthesis, which is essential for maturation of the red cells
Erythropoiesis ◆ Concept ot : The FETUS ADULT production of new 粪xal Skeleton red blood cells to Yolk Sac replace the old and died ones 0u.Osu Spleen ◆ In the adult. all the Bones rea cells are L 102030405060 produced in bone MON marrow 19
19 Erythropoiesis Concept: The production of new red blood cells to replace the old and died ones In the adult, all the red cells are produced in bone marrow
Erythropoiesis- Pluripotent stem cells in the bone marrow can produce any type of aau a blood cells lymphoid is capable of both self- FUGM Pre-B cells Prothymo。ye replication and Proerythroblast Megakaryoblast Monoblast Myeloblast myeloblast Basophilic B lymphoblast T lymphoblast differentiation to Reticulocyte Megakaryocyte committed precursors cells that can produce ocyte T lymphocyte only a specific cell line Plasma ce‖l CPU: colony forming unit
CPU： 20 colonyforming unit Erythropoiesis- Pluripotent stem cells ➢ in the bone marrow ➢ can produce any type of blood cells. ➢ is capable of both selfreplication and differentiation to committed precursorscells that can produce only a specific cell line
Erythropoiesis-CPU-E the committed red cell precursor undergoes several divisions The daughter cells becomes progressively smaller the cytoplasm changes color from blue to pink as hemoglobin is synthesized the nucleus becomes small and dense and then extrude Early intermediate Late Proerythroblast Polychromatophilic Reticulocyte (Pronormoblast Normoblast Basophilic Orthochromatophilic Erythrocyte Normoblast Normoblast
21 Proerythroblast (Pronormoblast) Basophilic Normoblast Polychromatophilic Normoblast Orthochromatophilic Normoblast Reticulocyte Erythrocyte Early Intermediate Late Erythropoiesis-CPU-E ➢ the committed red cell precursor undergoes several divisions. ➢ The daughter cells becomes progressively smaller, ➢ the cytoplasm changes color from blue to pink as hemoglobin is synthesized, ➢ the nucleus becomes small and dense and then extrude