Erythropoiesis-CPU-E The resulting non-nucleated cells is termed a reticulocyte since it still contains rNa Within a few days of entering the circulation, the reticulocytes lose their RNA and becomes mature red celIs Early Intermediate Late Proerythroblast Polychromatophilic Reticulocyte (Pronormoblast Normoblast Basophilic Orthochromatophilic Erythrocyte Normoblast Normoblast
22 Proerythroblast (Pronormoblast) Basophilic Normoblast Polychromatophilic Normoblast Orthochromatophilic Normoblast Reticulocyte Erythrocyte Early Intermediate Late Erythropoiesis-CPU-E ➢ The resulting non-nucleated cells is termed a reticulocyte since it still contains RNA. ➢ Within a few days of entering the circulation, the reticulocytes lose their RNA and becomes mature red cells
Importance of the Erythropoiesis Maintain the number of the red cells remarkable constant Anemia Decrease rate of erythropoiesis or increased rate of red cells destruction decreased number of red cells and weight of hemoglobin
23 Importance of the Erythropoiesis ➢ Maintain the number of the red cells remarkable constant ➢ Anemia ➢ Decrease rate of erythropoiesis or increased rate of red cells destruction ➢ decreased number of red cells and weight of hemoglobin
Regulation of Erythropoiesis A. Erythropoietin, a glycoprotein released predominantly from the kidneys in response to tissue hypoxia y also produced by reticuloendothelial system of the liver and spleen Effect a, Stimulates the proliferation and differentiation of the committed red cell precursor b, Accelerates hemoglobin synthesis C, Shortens the period of red development in the bone marrow
24 Regulation of Erythropoiesis ➢ A. Erythropoietin, ➢ a glycoprotein released predominantly from the kidneys in response to tissue hypoxia. ➢ also produced by reticuloendothelial system of the liver and spleen. ➢ Effect: ➢ a, Stimulates the proliferation and differentiation of the committed red cell precursor ➢ b, Accelerates hemoglobin synthesis ➢ c, Shortens the period of red development in the bone marrow
Regulation of Erythropoiesis >B. Other hormones stimulate erythropoiesis Adrenal cortical steroids >Pituitary growth hormone > Parathyroid hormone >Androgen >C. Estrogen -inhibit erythropoiesis 25
25 Regulation of Erythropoiesis ➢B. Other hormones stimulate erythropoiesis ➢Adrenal cortical steroids, ➢Pituitary growth hormone, ➢Parathyroid hormone ➢Androgen ➢C. Estrogen – inhibit erythropoiesis
White blood cells(leucocytes) >Leukocytes contain nuclei and mitochondria and can move in an amoeboid fashion >so they can squeeze through pores in capillary and get to a site of infection Number, 5000 to 10000/ul >Classification Granular leukocytes, having granules in the cytoplasm >Agranular(or nongranular) leukocytes: without granules in the cytoplasm
26 White blood cells (leucocytes) ➢Leukocytes contain nuclei and mitochondria and can move in an amoeboid fashion, ➢so they can squeeze through pores in capillary and get to a site of infection. ➢ Number, 5000 to 10000/µl ➢Classification: ➢Granular leukocytes, having granules in the cytoplasm; ➢Agranular (or nongranular) leukocytes: without granules in the cytoplasm