Hypothesis of Parkinson's disease pathogenesis Parkinson's disease results from the death of dopamine-generating cells in the substantia nigra,a region of the midbrain. The cause of this cell death is unknown
Hypothesis of Parkinson’s disease pathogenesis • Parkinson's disease results from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain. • The cause of this cell death is unknown
1997: April 11, World Parkinson's Disease Day (世界帕金森病日) In memory of the birth day of James Parkinson
1997: April 11, World Parkinson’s Disease Day (世界帕金森病日) In memory of the birth day of James Parkinson
What's the cause of this disease? Why only those neurons die? No exact idea. 1,Primary（原发性)，unknown 2,Secondary(继发性)to effects of chemicals:Mn2++,CO,pesticides, herbicides,rotenone,.. 3,Brain injury 4)
Why only those neurons die? No exact idea. 1, Primary （原发性 ）, unknown 2, Secondary （继发性 ）to effects of chemicals: Mn2++, CO, pesticides, herbicides, rotenone, … 3, Brain injury 4, …… What’s the cause of this disease?
1976,an American college student wanted to synthesize MPPP for drug abuse, but got MPTP due to preparation error Three days late,suffered from PD-like symptoms. Two years late,made suicide and the autopsy found damage in substantia nigra Given to monkeys,also suffered from similar symptoms “tool drug
1976, an American college student wanted to synthesize MPPP for drug abuse, but got MPTP due to preparation error Three days late, suffered from PD-like symptoms. Two years late, made suicide and the autopsy found damage in substantia nigra Given to monkeys, also suffered from similar symptoms “tool drug
Li HO Propionic N-CH3 Anhydride H2S04 N CH3 CH3 CH3 MP HPMP MPPP mptp MPTP(1-methyl-.4-phenyl--1,2,3,6-tetrahydropyridine,.甲苯四氢吡啶)， occasionally obtained in the preparation of MPPP MPPP(1-Methyl-4-phenyl-4-propionoxypiperidine )opioid compound
MPTP(1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine, 甲苯四氢吡啶）, occasionally obtained in the preparation of MPPP MPPP (1-Methyl-4-phenyl-4-propionoxypiperidine ), opioid compound