Caitkrriru Mi 73 t的 Handwriting of a person affected by PD in Lectures on the diseases of the nervous system by Charcot(1879)
Handwriting of a person affected by PD in Lectures on the diseases of the nervous system by Charcot (1879)
Parkinson's disease Many other symptoms: deficits in the sense of smell;fatigue; disturbances of the autonomic nervous system which controls blood pressure,urinary bladder,bowel and sexual function; sleep disorders; v a variety of behavioral features including anxiety and depression;and finally neuropsychological abnormalities including dementia
Many other symptoms: deficits in the sense of smell; fatigue; disturbances of the autonomic nervous system which controls blood pressure, urinary bladder, bowel and sexual function; sleep disorders; a variety of behavioral features including anxiety and depression; and finally neuropsychological abnormalities including dementia. Parkinson’s disease
Epidemiological data in China 1986 0.047% 2000 1.14%(Shanghai data 2006 2.0%(National data Mayo Clinic: lifetime risk of developing Parkinson's disease,2 for men and 1.3 for women
Epidemiological data in China 1986 0.047 % 2000 1.14% （Shanghai data ） 2006 2.0% （National data ） Mayo Clinic ： lifetime risk of developing Parkinson's disease ， 2 ％ for men and 1.3 ％ for women
Short history of Parkinson's disease study 4000 years ago,historical record 1817:British Doctor James Parkinson reported the disease 1953:found substantia nigra (as diseased site M960:DA↓in striatum 80%neurons loss in substantia nigra Reserpine(利舍平)exhausts DA,causing PD-ike symptoms Lesion of DA pathway in animal,PD-like symptoms 1961:L-dopa effective in the treatment of PD
4000 years ago, historical record 1817: British Doctor James Parkinson reported the disease 1953: found substantia nigra （黑质）as diseased site 1960: DA ↓in striatum 80 ％neurons loss in substantia nigra Reserpine (利舍平）exhausts DA, causing PD-like symptoms Lesion of DA pathway in animal, PD-like symptoms 1961: L-dopa effective in the treatment of PD Short history of Parkinson’s disease study
Ventricles Thalamus Frontal cortex Substantia Nigra Striatum Hypothalamus serolonin pathwoy ■ dopamine pathway (nigrostriatial) Brainstem dopamine pathway (mesolimbic)