(A)Vinblastine (B)Doxorubicin (Adriamycin)(C)Busulfan (D)Bleomycin (E)Cisplatin 2.Kernicterus in newborn or premature infants treated with sulfonamides is due to (A)Enhanced synthesis of bilirubin (B)Displacement of bound bilirubin from albumin (C)Inlhibition of bilimbin degradation (D)Inhibition of urinary excretion of bilirubin (E)Deposition of crystalline aggregates in the kidneys 3.Aluminum and calcium salts inhibit the intestinal absorption of which of the following agents? (A)Isoniazid (B)Chloramphenicol (C)Penicillin V (D) Erythromycin (E)Tetracycline 4.The drug most effective against malarial parasites in the liver but not effective against parasites within erythrocytes is (A)Primaquine (B)Pyrimethamine (C)Quinine (D)Chloroquine (E)Artemisinin 5.Sulfisoxazole specifically inhibits which of the following processes? (A)Conversion of tetrahydrofolic acid to dihydrofolic acid (B)Converting deoxyuridine mono phosphate to thymine ribonucleoside monophosphate (C)Synthesis of methionine and serine (D)Synthesis of pteroylglutamic acid(dihydrofolic acid) (E)Reduction of ribonucleotides
(A) Vinblastine (B) Doxorubicin (Adriamycin) (C) Busulfan (D) Bleomycin (E) Cisplatin 2. Kernicterus in newborn or premature infants treated with sulfonamides is due to (A) Enhanced synthesis of bilirubin (B) Displacement of bound bilirubin from albumin (C) Inlhibition of bilimbin degradation (D) Inhibition of urinary excretion of bilirubin (E) Deposition of crystalline aggregates in the kidneys 3. Aluminum and calcium salts inhibit the intestinal absorption of which of the following agents? (A) Isoniazid (B) Chloramphenicol (C) Penicillin V (D) Erythromycin (E) Tetracycline 4. The drug most effective against malarial parasites in the liver but not effective against parasites within erythrocytes is (A) Primaquine (B) Pyrimethamine (C) Quinine (D) Chloroquine (E) Artemisinin 5.Sulfisoxazole specifically inhibits which of the following processes? (A) Conversion of tetrahydrofolic acid to dihydrofolic acid (B) Converting deoxyuridine mono phosphate to thymine ribonucleoside monophosphate (C) Synthesis of methionine and serine (D) Synthesis of pteroylglutamic acid(dihydrofolic acid) (E) Reduction of ribonucleotides
6.In the treatment of gonococcal infection in adults,the drug of choice is (A)Pyrimethamine (B)Benzathine penicillin G (C)Penicillin G (D)Erythromycin (E)Tetracycline 7.Indicate from the diagram below the site of action of penicillinase. (A)A (B)B (C)C (D)D (E)E 8.Clavulanic acid,a new type of B-lactam antibiotic,is important because it (A)Easily penetrates gram-negative microorganisms (B)Is specific for gram-positive microorganisms (C)Is a potent inhibitor of cell wall transpeptidase (D)Inactivates bacterial B-lactamases (E)Has a spectrum of activity similar to penicillin G 9.In the treatment of infections caused by Pseudomonas aeruginosa,the antimicrobial agent that has proven to be effective is (A)penicillin G (B)carbenicillin (C)oxacillin (D)erythromycin (E)tetracycline 10.The therapy of choice in the treatment of meningococcal meningitis is
6. In the treatment of gonococcal infection in adults, the drug of choice is (A) Pyrimethamine (B) Benzathine penicillin G (C) Penicillin G (D) Erythromycin (E) Tetracycline 7. Indicate from the diagram below the site of action of penicillinase. (A) A (B) B (C) C (D) D (E) E 8. Clavulanic acid, a new type of ß-lactam antibiotic, is important because it (A) Easily penetrates gram-negative microorganisms (B) Is specific for gram-positive microorganisms (C) Is a potent inhibitor of cell wall transpeptidase (D) Inactivates bacterial ß-lactamases (E) Has a spectrum of activity similar to penicillin G 9. In the treatment of infections caused by Pseudomonas aeruginosa, the antimicrobial agent that has proven to be effective is (A) penicillin G (B) carbenicillin (C) oxacillin (D) erythromycin (E) tetracycline 10. The therapy of choice in the treatment of meningococcal meningitis is
(A)erythromycin,intravenously (B)amphotericin B,intravenously (C)penicillin G,intravenously (D)streptomycin,intramusclarly (E)tetracycline,intravenously 11.Ethambutol is administered concurrently with other antitubercular drugs in the treatment of tuberculosis in order to (A)reduce the pain of injection (B)facilitate penetration of the blood brain barrier (C)retard the development of organism resistance (D)delay excretion of other antitubercular drugs by the kidney (E)retard absorption after intramuscular injection 12.Antimetabolic drugs include all the following EXCEPT (A)cyclophosphamide (B)cytarabine (C)5-fluorouracil (D)6-mercaptopurine (E)methotrexate 13.The aminoglycoside most likely to remain a useful therapeutic agent in the event of gentamycin resistance is (A)streptomycin (B)amikacin (C)neomycin (D)penicillin G (E)kanamycin 14.The drug used both in the treatment of active tuberculosis and most commonly in the chemoprophylaxis of tuberculosis is (A)ethambutol (B)cycloserine (C)streptomycin (D)isoniazid (E)p-aminosalicylic acid 15.Which of the following statements about the neurotoxicity of isoniazid is true? (A)It can be prevented by streptomycin (B)It can be treated with vitamin Bl
(A) erythromycin, intravenously (B) amphotericin B, intravenously (C) penicillin G, intravenously (D) streptomycin, intramusclarly (E) tetracycline, intravenously 11. Ethambutol is administered concurrently with other antitubercular drugs in the treatment of tuberculosis in order to (A) reduce the pain of injection (B) facilitate penetration of the blood brain barrier (C) retard the development of organism resistance (D) delay excretion of other antitubercular drugs by the kidney (E) retard absorption after intramuscular injection 12. Antimetabolic drugs include all the following EXCEPT (A) cyclophosphamide (B) cytarabine (C) 5-fluorouracil (D) 6-mercaptopurine (E) methotrexate 13. The aminoglycoside most likely to remain a useful therapeutic agent in the event of gentamycin resistance is (A) streptomycin (B) amikacin (C) neomycin (D) penicillin G (E) kanamycin 14. The drug used both in the treatment of active tuberculosis and most commonly in the chemoprophylaxis of tuberculosis is (A) ethambutol (B) cycloserine (C) streptomycin (D) isoniazid (E) p-aminosalicylic acid 15. Which of the following statements about the neurotoxicity of isoniazid is true? (A) It can be prevented by streptomycin (B)It can be treated with vitamin B1
(C)It is responsive to pyridoxine therapy (D)It only occurs in toxic dose level (E)It interferes with the therapeutic effect 16.Candidiasis of the vagina,gastrointestinal tract,and oral cavity is treated primarily by which of the following drugs? (A)Nystatin (B)Miconazole (C)Rifampin (D)Griseofulvin (E) Iodide 17.Amoxicillin,a semisynthetic penicillin that resembles ampicillin EXCEPT for (A)spectrum of activity (B)more absorption after oral (C)skin rash (D)hypersensitivity reactions (E)CNS penetration 18.For the treatment of a patient with Legionella pneumonia,the drug of (A)penicillin G (B)chloraphenicol (C)erythromycin (D)SMZ (E) lincomyin 19.A possible treament for Mycoplasma pneumoniae would be (A)penicillin G (B)tetracycline (C)vancomycin (D)gentamycin (E)bacitracin 20.Cephalothin,a first generation cephalosporin,has antibacterial activity based on a mechanism of action that includes (A)interference with cross linking of peptidoglycan strands (B)competitive antagonism of pteroylglutamic acid synthesis (C)functiona]alteration of 30 S ribosomal synthesis (D)inhibition of nucleic acid synthesis (E)inhibition of protein synthesis 21 The nucleophilic attack on DNA causing the disruption of base pairing occurs as a result of which of the following drug?
(C) It is responsive to pyridoxine therapy (D) It only occurs in toxic dose level (E) It interferes with the therapeutic effect 16. Candidiasis of the vagina, gastrointestinal tract, and oral cavity is treated primarily by which of the following drugs? (A) Nystatin (B) Miconazole (C) Rifampin (D) Griseofulvin (E) Iodide 17. Amoxicillin, a semisynthetic penicillin that resembles ampicillin EXCEPT for (A) spectrum of activity (B) more absorption after oral (C) skin rash (D) hypersensitivity reactions (E)CNS penetration 18. For the treatment of a patient with Legionella pneumonia, the drug of (A) penicillin G (B)chloraphenicol (C) erythromycin (D) SMZ (E) lincomyin 19. A possible treament for Mycoplasma pneumoniae would be (A) penicillin G (B) tetracycline (C)vancomycin (D)gentamycin (E)bacitracin 20. Cephalothin, a first generation cephalosporin, has antibacterial activity based on a mechanism of action that includes (A) interference with cross linking of peptidoglycan strands (B) competitive antagonism of pteroylglutamic acid synthesis (C) functiona] alteration of 30 S ribosomal synthesis (D) inhibition of nucleic acid synthesis (E) inhibition of protein synthesis 21 The nucleophilic attack on DNA causing the disruption of base pairing occurs as a result of which of the following drug?
(A)Cyclophosphamide (B)Fluorouracil (C)Methotrexate (D)Prednisone (E)Thioguanine 22.All the following penicillins are resistant to penicillinase EXCEPT (A)oxacillin (B)cloxacillin (C)amoxycillin (D)nafcillin (E)dicloxacillin 23.Chloramphenicol is the drug of choice for the treatment of (A)typhoid fever (B)gonorrhea (C)S.aureus infections (D)anthrax (E)gas gangrene II.Type K:DIRECTIONS:Each question below contains four suggested answers of which one or more is correct.Choose the answer: A if 1,2.and3 are correct B if 1 and 3 are correct C if 2 and 4 are correct D if are correct E if 1,2,3,and4 are correct 24.Streptomycin and other aminoglycosides inhibit bacterial protein synthesis by binding to (1)peptidoglycan units in the cell wall (2)messenger RNA (3)DNA (4)30 S ribosomal subunit 25.True statements concerning griseofulvin include that it (1)inhibits the growth of dermatophytes (2)inhibits cell wall synthesis (3)is administered primarily by the oral route (4)is used primarily as a short-term drug
(A) Cyclophosphamide (B) Fluorouracil (C) Methotrexate (D) Prednisone (E) Thioguanine 22. All the following penicillins are resistant to penicillinase EXCEPT (A) oxacillin (B) cloxacillin (C) amoxycillin (D) nafcillin (E) dicloxacillin 23. Chloramphenicol is the drug of choice for the treatment of (A) typhoid fever (B) gonorrhea (C) S. aureus infections (D) anthrax (E) gas gangrene II.Type K: DIRECTIONS: Each question below contains four suggested answers of which one or more is correct. Choose the answer: A if 1, 2, and 3 are correct B if 1 and 3 are correct C if 2 and 4 are correct D if 4 are correct E if 1, 2, 3, and 4 are correct 24. Streptomycin and other aminoglycosides inhibit bacterial protein synthesis by binding to (1) peptidoglycan units in the cell wall (2) messenger RNA (3) DNA (4) 30 S ribosomal subunit 25. True statements concerning griseofulvin include that it (1) inhibits the growth of dermatophytes (2) inhibits cell wall synthesis (3) is administered primarily by the oral route (4) is used primarily as a short-term drug