山BIOCHEMISTRYANDMOLECULARBIOLOGYStructure of DNAComponent of nucleic acid1. Component of elementC、H、O、N、P (9~10%)2. Molecular component (basic component unitis nucleotide or deoxynucleotide) Base: Purine, PyrimidineRibose: Ribose, DeoxyribosePhosphateDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Structure of DNA Component of nucleic acid 1. Component of element C、H、O、N、P（9~10%） 2. Molecular component (basic component unit is nucleotide or deoxynucleotide) —— Base：Purine，Pyrimidine —— Ribose：Ribose，Deoxyribose —— Phosphate
NH2BIOCHEMISTRYANDMOLECULARBIOLOGYNBase(purineandpyrimidine2NHN67(adenine, A)58249O3NHNNNHPurineNHNH2N(guanine, G)Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Purine N N NH N 1 2 3 4 5 6 7 8 9 N N NH N NH2 (adenine, A) N NH NH N NH2 O (guanine, G) Base(purine and pyrimidine)
?BIOCHEMISTFANDMOLECULARBIOLOGYNH4N5326入NH中NHPyrimidine(uracil, U)ONH2H3CNHNH?NH(thymine. T)C)(cytosine,Department of Biochemistry and Molecular Biology,MedicineSchool
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY N NH 1 3 2 4 5 6 Pyrimidine (cytosine, C) N NH NH2 O (uracil, U) NH NH O O (thymine, T) NH NH O O H3 C
BIOCHEMISTRYANDMOLECULARBIOLOGYPentoseHO—CH2HO—CH2OHOH5O142'3OHOHOH(ribose)(deoxyribose)(DNA)(RNA)Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Pentose （RNA） 1´ 3´ 2´ 4´ 5´ OH O HO CH2 OH OH (ribose) （DNA） OH O HO CH2 OH (deoxyribose)
BIOCHEMISTRYANDMOLECULARBIOLOGYRibonucleosideBase link ribose or deoxyribose byNH2glycosidic bond to form ribonucleoside.Ribonucleoside: AR, GR, UR, CRHO-CH2Deoxyribonucleoside: dAR, dGR.dTR, dCROH OHDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY Ribonucleoside：AR, GR, UR, CR Deoxyribonucleoside：dAR, dGR, dTR, dCR Ribonucleoside Base link ribose or deoxyribose by glycosidic bond to form ribonucleoside. HO O C H2 OH OH N N NH2 O 1´ 1