用曲 Deep-Kcr:accurate detection of lysine crotonylation sites using deep learning method /966 可▣ Center for Information Biology,UESTC,China,Chengdu 司第 Hao Lin INDING 2020-09- Group
Center for Information Biology, UESTC, China, Chengdu Hao Lin 2020-09- Deep-Kcr: accurate detection of lysine crotonylation sites using deep learning method
INDING Group 956 蛋白质翻译后修饰(PTM)的类型 Phosphorylation Phosphorylation Hanks-type kinases Phosphorylation TCS TCS.PTS Glycosylation Aspartate Phosphorylation PTS Histidine O-glycosyltransferases Phosphorylation OH Serine Lipidation Diacylglyceryl OH transferases Hanks-type kinases HO Cysteine Thiolation Thiol peptides HS OH Glycosylation Threonine Protein O-glycosyltransferases Oxidation Methionine OH Methionine sulfoxide reductases NH. Phosphorylation NH NH BY kinases Tyrosine Asparagine N Glycosylation N-glycosyltransferases Arginine Lysine Phosphorylation Glycosylation Acetylation Acylation Arg kinases N-glycosyltransferases Acetyltransferases Acyltransferases Pupylation Non-enzymatic? Pup ligases 1 Macek et al.Nature Review Genetics 2019
1 蛋白质翻译后修饰 (PTM) 的类型 Macek et al. Nature Review Genetics 2019
INDING Group 9s6 组蛋白巴豆酰化(Kcr)的发生过程 DNA转录为mRNA并出核 mRNA d Ribosomal 核糖体将mRNA翻译成蛋白质 subunits Amino acids Peptide chain lysine RNA 蛋白质穿过内质网、高尔基体 包装 Crotonyl lysine ribosome 进入囊泡 巴豆酰基 Kcr的翻译后修饰 囊泡中，蛋白质被共价修饰 2
2 组蛋白巴豆酰化(Kcr)的发生过程 Kcr的翻译后修饰 DNA转录为mRNA并出核 核糖体将mRNA翻译成蛋白质 蛋白质穿过内质网、高尔基体 进入囊泡 包装 巴豆酰基 囊泡中，蛋白质被共价修饰
24N9 Group Kcr功能：调控精子发生的成熟过程 Cell Resource Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification 中国科学院生物 图 Minjia Tan.Hao Luo.Sangkyu Lee Fulai Jin,Jeor and YingingYen hu Joanina WocYang Ye. Nish Ben May Department of Canoor Research,The University of Chicago,Chicago,IL 80637,USA udwig institute for Cancer Research and Department af Celluar and Molecular Medicine,Universty of Caitomia San Diego School of 4 ledcine,9500 Giman Drt，La Jola.CAg20G3.5A INSERM.UB23:Universite Joseph Fourier-Grenoble 1:Institut Albert Bonniot.Facut de Mddecine,Domaine de la Merci. 38706 La Tronche Cedex.France Shanghai Institute of Materia Medica.Chinese Academy of Sciences,555 Zu Chong Zhi Road Shanghai 201203,P.R.China Department ol Chemical and Systems Biology.Starford University School of Medicine,Starlord.CA 94305.USA Dr.Yingming Zhao 0010.1018c201108.008 M MIV VII VII X细 Hyper-crotonylation wave in elongating spermatids 9-11 3 图巴豆酰化修饰促进精子发育成熟
3 Kcr功能：调控精子发生的成熟过程 Dr. Yingming Zhao 图 巴豆酰化修饰促进精子发育成熟
INDING Group Kcr调控压力胁迫下的抑郁症反应 ARTICLE IN PRESS Archival Report Chromodomain Y-like Protein-Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors Yongqing Liu,Minghua Li,Minghua Fan,Yan Song,Huajing Yu,Xiaojie Zhi,Kuo Xiao, Shirong Lai,Jingliang Zhang,Xueqin Jin,Yongfeng Shang,Jing Liang,and Zhuo Huang Dr.Jing Liang Control or Resilient CDYL EZH2 SStOISY PL dendritic spines CDYL Susceptible EZH2 CDYL CDYL Dendritic spines loss H3K27me3 PanKcr 4 图转录抑制因子CDYL和巴豆酰化修饰降低转录抑制神经肽VGF的表达从而促进抑郁症
4 Kcr调控压力胁迫下的抑郁症反应 图 转录抑制因子CDYL和巴豆酰化修饰降低转录抑制神经肽VGF的表达从而促进抑郁症 Dr. Jing Liang