1 SYNTHESIS OF NOREPINEPHRINE ·dra8 m UPTAKE INTO STORAGE VESICLES MAO美 56ote 。Tb22te8ae8 MAO RELEASE OF NEUROTRANSMITTER unretyilum REMOVAL OF NOREPINEPHRINE apidlyr eake。nmpn mt。 Catechol-O COM SYNAPTIC METABOLISM SPACE INTRACELLULAR RESPONSE e6.3 esis and release of norepinephrine from the adrenergic neuron
Adrenergic receptor a,B were initially identified on the basis of their responses the adrenergic agonists,epinephrine,norepinephrine, isoproterenol ■ a receptors have a higher affinity for phenylephrine.The drug clonidine selectively binds to a2 receptors
Adrenergic receptor ◼ , were initially identified on the basis of their responses the adrenergic agonists, epinephrine, norepinephrine, isoproterenol ◼ 1 receptors have a higher affinity for phenylephrine. The drug clonidine selectively binds to 2 receptors
A x Adrenoceptors a Receptor BB Adrenoceptors a aflinily Figure 6.4 Types of adrenergic receptors
a1 receptors these receptors are present on the postsynaptic membrane of the effector organs.G-protein coupling
1 receptors ◼ these receptors are present on the postsynaptic membrane of the effector organs. G-protein coupling
areceptors Located primarily on the presynaptic nerve endings and on other cells. The stimulation of the apreceptors causes feedback inhibition of the ongoing release of norepinephrine from the stimulated adrenergic neuron
2 receptors ◼ Located primarily on the presynaptic nerve endings and on other cells. ◼ The stimulation of the 2 receptors causes feedback inhibition of the ongoing release of norepinephrine from the stimulated adrenergic neuron