BIOCHEMISTRYANDMOLECULARBIOLOGY1.overview Proteins display an incredible diversity of functions> All protein share the common structural featureof being linear polymers of amino acidDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 1. overview ➢ Proteins display an incredible diversity of functions. ➢ All protein share the common structural feature ➢ of being linear polymers of amino acid
BIOCHEMISTRYANDMOLECULARBIOLOGY1.overview This chapter describes the properties of amino acids> Next chapter explores how these simple buildingblocks are joined to form proteins that have uniquethree-dimensional structures, making them capable ofperforming specific biologic functionDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY 1. overview ➢ This chapter describes the properties of amino acids. ➢ Next chapter explores how these simple building blocks are joined to form proteins that have unique three-dimensional structures, making them capable of performing specific biologic function
2.StructureofaminoacidAlthough morethan 3o0 differentamino acids have beendescribedin nature,only20 are commonlyfoundasconstituents of mammalian protein.All these amino acids areLa-aminoacids(Exceptglycine)Carboxyl groupCOOHAmino groupHRSide chaina-carbonatom
2 . Structure of amino acid • Although more than 300 different amino acids have been described in nature, only 20 are commonly found as constituents of mammalian protein. All these amino acids are L—α—amino acids(Except glycine). H2N C H COOH R Side chain α-carbon atom Amino group Carboxyl group
1BIOCHEMISTRYANDMOLECULARBIOLOGYAFreeaminoacidCommontoallα-aminoacidsofproteinsCOOH+HNCa-H-7RCarboxylAminogroupgroupSide chainα-Carbonisis distinctivebetweentheforeachaminocarboxylandtheacid.aminogroups.Department of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY
ABIOCHEMISTRYANDMOLECULARBIOLOGYCOOC+NH3CHAlanineGlycineCommonstructureofaminoacidsExcept proline all of amino acids have these structureDepartment of Biochemistry and Molecular Biology,Medicine School
Department of Biochemistry and Molecular Biology, Medicine School BIOCHEMISTRY AND MOLECULAR BIOLOGY H Glycine CH3 Alanine Common structure of amino acids R C + NH3 COO - H Except proline all of amino acids have these structure