2)Bacterialinfection(l)pathogenicbacteriaStaphylococcus aureus口Streptococcus口Ecoli口Salmonella口Pneumococcus口Anaerobic bacterium1Staphylococcus epidermidis, etc口(2)Pathogenesis: toxic hepatitis of sepsis(3)Clinical features:subclinical sepsis(4)Common points ofentry:oral mucosa, unbilical region,respiratorytract,urinary tract, skin, etc
2) B a c t e r i a l i n f e c t i o n ( 1 ) pathogenic bacteria □ Staphyloc occus a u reu s □ Strep tococcu s □ E coli □ Salmonella □ P n eu mococcu s □ Anaerobic bacterium □ Staphyloc occus epidermidis，etc (2) Pathogenesis： toxic hepatitis of sep sis (3) Clinical features：subclinical sep sis (4)Common points of entry： oral mucosa, unbilical region, respiratory tract, urinary tract, skin, etc
3)Otherinfectionpathogens:Toxoplasm:口Congenital ToxoplasmosisMicrospironema pallidum口Congenital syphilisFungous infection,etc
3) Other infection pathogens： □ Toxoplasm: Congenital Toxoplasmosis □ Microspironema pallidum: Congenital syphilis □ Fungous infection, etc
TORCH:TToxoplasmaOOthers R-Rubella virusCytomegalovirusHHerps symplex virus
TORCH： T—Toxoplasma O—Others R— Rubella virus C— Cytomega lovirus H—Herps symplex virus
2.Hereditary andgenetic metabolic disorders1)Carbohydratedysmetabolism Galactosemisgalactose-l-phosphate uridyltransferase deficiency deficiency Fructoseintolerancefructose bisphosphatealdolase Pompe's syndrome1)Aminoacid dysmetabolismTyrosinemia3)LipiddysmetabolismNiemann-Pick ‘sdisease, Gaucher disease or Wolman' s disease4)Otherdysmetabolism
2.Hereditary and genetic metabolic disorders 1)Carbohydrate dysmetabolism □ Galactosemis galactose-1-phosphate uridyltransferase deficiency deficiency □ Fructose intolerance fructose bisphosphate aldolase □ Pompe's syndrome 1)Amino acid dysmetabolism Tyrosinemia 3)Lipid dysmetabolism Niemann-Pick‘s disease, Gaucher disease or Wolman’s disease 4)Other dysmetabolism
Galactosemislactosegalactose +glucosegalactokinasel-galactosephosphategalactose-l-phosphate uridyltransferase1-glucosephosphateClinical features:Vomiting, difficult feeding, hypoglycemia, alack of energy,failure to thrive, cataract, jaundice, hepatomegaly , liver cirrhosis,mental retardation after several days ofmilk feedingBiochemistryexaminationblood glucosel, blood galactoset, reducing sugar test +Diagnos is : enzymatic determination
lactose □ Dia gn osis: enzymatic determination Galactosemis galactos e + glu cose galactokinase 1-galactose phosphate galactose -1-phos phate uridyltransferase 1-glucose phosphate □ Clinical features： Vomiting, difficult feeding, hypoglycemia, a lack of energy, failure to thrive, cataract, jaundice, hepatomegaly , liver cirrhosis, mental retardation after several days of milk feeding. □ Biochemistry examination: blood glucose↓, blood galactose↑, reducing sugar test +