[Pathogenesis]The prerequisites ofToxic Bacillary Dysentery occurring:l. Toxicityinvasivenessattachment中penetration口multiplicationendotoxin日2. Host idiosyncrasy and responsivity
[Pathogenesis] The prerequisites of Toxic Bacillary Dysentery occurring： 1. Toxicity □ invasiveness □ attachment □ penetration □ multiplication □ endotoxin 2.Host idiosyncrasy and responsivity
Intestine (sigmoid colon andrectum)dysenterybacilliinvasivenessmultiplyinepithelia cell & proper laminaToxinsexotoxinendotoxinendotoxemiamucous hyperemia, edema, effusionbioactive compounds orPyrogen ofInflammatory Mediators (SIRS)WBCsuperficial mucosal necrosis and ulcermicro-circulatory failureChill, fever Septic Shock, cerebraledema,abdominalpain, diarrhea,DIC,MOFSstoolmixed withblood& pus,tenesmus
dysente ry bacilli Intestine (sigmoid colon and rectum) invasiveness multiply in epithelia cell & proper lamina Toxins endotoxin exotoxin endotoxemia mucous hyperemia, edema, effusion bioactive compounds or Inflammatory Mediators (SIRS) superficial mucosal necrosis and ulcer micro-circulatory failure abdominal pain, diarrhea, stool mixed with blood & pus, tenesmus Pyrogen of WBC Chill, fever Septic Shock, cerebral edema, DIC, MOFS
1Construction of Normal MicrocirculatoryStagnantmicro-circulatoryMicrocirculationIschemiaStageHypoxicFailurestageStageMicrocirculationFailureStages
Microcirculation Failure Stages Construction of Normal Microcirculatory Microcirculation Ischemia Stage Stagnant Hypoxic Stage micro-circulatory Failure stage