Constitutive Defenses Barriers to entry See Schaechter text table 6.1 Mucous membranes--covered by protective layer of mucus Mechanical and chemical barrier that allows proper functioning Cross-linked gel structure composed of glycoprotein subunits BIOL 533 Lecture 5
BIOL 533 2 Lecture 5 Constitutive Defenses • Barriers to entry – See Schaechter text, Table 6.1 • Mucous membranes—covered by protective layer of mucus – Mechanical and chemical barrier that allows proper functioning • Cross-linked gel structure composed of glycoprotein subunits
Mucus membranes Entraps particles and prevents them from getting to mucus membrane Hydrophilic: allows passage of a number of bodily substances Antimicrobial substances(lysozyme and peroxidase) Can withstand substantial weight but still be propelled by cilia BIOL 533 Lecture 5
BIOL 533 3 Lecture 5 Mucus Membranes • Entraps particles and prevents them from getting to mucus membrane – Hydrophilic: allows passage of a number of bodily substances • Antimicrobial substances (lysozyme and peroxidase) • Can withstand substantial weight, but still be propelled by cilia
Defenses of Deep Tissues带 Role of constitutive defenses List of humoral mediators of constitutive defenses(See Schaechter text, Table 6.2) BIOL 533 Lecture 5
BIOL 533 4 Lecture 5 Defenses of Deep Tissues • Role of constitutive defenses – List of humoral mediators of constitutive defenses (See Schaechter text, Table 6.2)
Defenses of Deep Tissues带 Role of constitutive defenses contd Inflammatory response does not require previous contact with microorganism Elicited by complex effectors many of which are complement system Normally at basal level and must be further increased by presence of microorganisms in tissues Most important consequence of activity is phagocyte attraction BIOL 533 Lecture 5
BIOL 533 5 Lecture 5 Defenses of Deep Tissues • Role of constitutive defenses, cont’d. – Inflammatory response does not require previous contact with microorganism – Elicited by complex effectors, many of which are complement system • Normally at basal level and must be further increased by presence of microorganisms in tissues – Most important consequence of activity is phagocyte attraction
Defenses of Deep Tissues带 Interaction of constitutive(inflammatory response) and inducible defenses (immune response) Inducible response cannot occur without constitutive mediators Mediators lead to induction of immune response and also defend against microbial invader BIOL 533 Lecture 5
BIOL 533 6 Lecture 5 Defenses of Deep Tissues • Interaction of constitutive (inflammatory response) and inducible defenses (immune response) – Inducible response cannot occur without constitutive mediators • Mediators lead to induction of immune response and also defend against microbial invader