细胞科学 Science 蔡国
细胞科学 Cell Science （10.4） 蔡国平
10.4 Intermediate filament I. The molecule structure of f 1)1Onm filament showing a similar spatial pattern as MT, to which they may be connected 2) To today, IF have only been identified with certainly in animal cells(?. Plant cells) 3)The model for IF assembly and architecture Monomer (a pair of globular terminal domains,a long a-helical region Dimer(homodimer or heterodimer), in parallel, ends d aligne Tetramer, in antiparallel, basic subunit. Lacking polarity IF structure, being composed of staggered subunits Highly resistant to tensile: and more resistant to chemical disruption
10.4 Intermediate filament 1. The molecule structure of IF 1) 10nm filament showing a similar spatial pattern as MT, to which they may be connected. 2) To today, IF have only been identified with certainly in animal cells (?. Plant cells) 3) The model for IF assembly and architecture: Monomer (a pair of globular terminal domains , a long -helical region. Dimer (homodimer or heterodimer), in parallel, ends aligned Tetramer, in antiparallel, basic subunit. Lacking polarity IF structure, being composed of staggered subunits, Highly resistant to tensile and more resistant to chemical disruption
coo coiled- coil dimer COOH NHz COoH COOH Hz COOH staggered tetramer of two coiled-coil dimers two tetramers packed together eight tetramers twisted into a rope 10 nm
a heikal rod domain imino terminus arbor term rewoldament p/ote regions containing heptad repeats
Central rod domain C Polypeptide N Head Coiled-coil Dimer Tetramer Protofilament 器∞∞ Filament